Results 11 to 20 of about 595 (104)

Mapping the neurovascular landscape in aging and dementia: cerebral small vessel disease markers in a multicenter Latin American cohort. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Cerebral small vessel disease (CSVD) is a key contributor to cognitive impairment and dementia, yet few studies have compared CSVD across dementia variants, particularly in underrepresented populations. METHODS In a multicenter cross‐sectional study, we analyzed magnetic resonance imaging (MRI) markers of CSVD, including white ...
Altschuler F, Castro-Laguardia AM, Canziani V, O'Byrne DF, Hazelton J, Migeot J, Maito M, García AM, Bruno MA, Magrath N, Slachevsky A, Behrens MI, Custodio N, Ávila-Funes JA, Matallana D, Aguillón D, Santamaria-García H, Resende E, Takada L, Brusco LI, Yokoyama JS, Miller B, Ibáñez A, Medel V, Campo CG.   +24 more
europepmc   +2 more sources

Cardiovascular risk factors and the allostatic interoceptive network in dementia [PDF]

Alzheimers Dement
Abstract Background Cardiovascular risk factors, such diabetes, hypertension, blood pressure, obesity, and smoking, are linked with allostatic‐interoception – the continuous monitoring of internal bodily states in anticipation of environmental demands. These risk factors are associated with dementia risk.
Hazelton J, Migeot J, Gonzalez‐Gomez R, Altschuler F, Duran‐Aniotz C, Wen O, Rial D, Barttfeld P, Medel V, Campo C, Laguardia A, Hernandez H, Gonzalez‐Silva C, Castaner O, Hu K, Li P, Behrens M, Bruno M, Cardona J, Custodio N, Santamaria‐Garcia H, Garcia A, Godoy M, Alberto Ávila Funes J, Maito M, Matallana D, Miller B, Lopera F, de Oliveira M, Pina‐Escudero S, Possin K, de Paula E, Resende F, Reyes P, Slachevsky A, Sosa A, Takada L, Yokoyama J, Ibanez A.   +38 more
europepmc   +3 more sources

Altered spatiotemporal brain dynamics of interoception in behavioural‐variant frontotemporal dementia [PDF]

Alzheimers Dement
Abstract Background Dysfunctional allostatic‐interoception, altered processing of bodily signals in response to environmental demands, occurs in behavioural‐variant frontotemporal dementia (bvFTD) patients. Previous research, however, has focused on static measures of interoception (e.g., heart‐evoked potential, HEP).
Hazelton J, Bella G, Barttfeld P, Dottori M, Gonzalez‐Gomez R, Migeot J, Moguilner S, Legaz A, Hernandez H, Prado P, Cuadros J, Maito M, Fraile‐Vazquez M, Gadea M, Çatal Y, Miller B, Piguet O, Northoff G, Ibanez A.   +18 more
europepmc   +3 more sources

Predicting brain health in older adults through automated language measures [PDF]

Alzheimers Dement
Abstract Background With increasing life expectancy, aging‐related neurocognitive challenges are becoming more prevalent worldwide. A continuum of severity, from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and Alzheimer's disease dementia (ADD), is measurable through cognitive and neuroimaging assessments.
Pérez G, Caro I, Bisé J, Ferrante F, Gauder L, Welford A, Ponferrada J, Ferrer L, Ibanez A, Slachevsky A, Garcia A.   +10 more
europepmc   +2 more sources

Enhancing MCI Assessment: A Digital Trail Making Test with Integrated Eye and Hand Tracking [PDF]

Alzheimers Dement
Abstract Background We extended our computerized Trail Making Test (c‐TMT) to investigate deficits in Mild Cognitive Impairment (MCI) compared to neurotypical controls. By integrating hand and eye tracking, we captured fine‐grained movement dynamics, revealing distinct trajectory alterations in MCI patients.
Juantorena G, Berrios W, Fernández M, Ibanez A, Petroni A, Kamienkowski J.   +5 more
europepmc   +3 more sources

A machine learning approach for a multidimensional analysis of functional phenotype allows for a better measurement of dementia and its severity [PDF]

Alzheimers Dement
Abstract Background Functional impairment (FI) is a key component in diagnosing and monitoring the severity of neurodegenerative dementia (ND). It manifests in several dimensions, such as everyday cognition, mobility, social functioning, and activities of daily living (ADLs).
Muñoz C, Custodio N, Montesinos R, Custodio B, Bustamante‐Paytan D, Dominguez C, Gallardo Á, Campo C, Lillo P, Farías G, Cerda M, Slachevsky A.   +11 more
europepmc   +2 more sources

Biological embedding of educational disparities in aging and neurodegeneration across global settings [PDF]

Alzheimers Dement
Abstract Background While education is crucial for brain health, evidence mainly relies on individual measures of years of education (YoE), neglecting educational quality (EQ). Whether YoE and EQ have complementary impacts on aging and dementia is unknown. Methods We assessed the impact of EQ and YoE on brain health in 7,533 subjects from 20 countries,
Gonzalez‐Gomez R, Hernandez H, Migeot J, Cruzat J, Legaz A, Fittipaldi S, Maito M, Medel V, Tagliazucchi E, Barttfeld P, O'Byrne D, Laguardia A, Alberto Ávila Funes J, Behrens M, Custodio N, Farombi T, Garcia A, Cordero I, Godoy M, Campo C, Hu K, Lawlor B, de Oliveira M, Pina‐Escudero S, Possin K, de Paula E, Resende F, Reyes P, Slachevsky A, Takada L, Valcour V, Whelan R, Yener G, Yokoyama J, Coronel‐Oliveros C, Ibanez A.   +35 more
europepmc   +3 more sources

The glymphatic system's role in linking cardiometabolic health to cerebral small vessel disease and frailty in Chilean healthy older adults [PDF]

Alzheimers Dement
Abstract Background Cardiometabolic factors such as elevated blood pressure, body mass index, cholesterol, and glucose levels are well‐known for their role in cardiovascular disease risk, but they also significantly impact brain structure and function, particularly in aging populations.
Laguardia A, O'Byrne D, Campo C, Delano P, Farías G, Ibanez A, Delgado C, Medel V.   +7 more
europepmc   +2 more sources

Sex Differences in the Association Between Cardiovascular Factors and White Matter Hyperintensities in a Latin American Cohort [PDF]

Alzheimers Dement
Abstract Background Dementia incidence and progression differ between men and women, with women showing increased vulnerability. Sex differences in cerebrovascular pathology may contribute to variations in neurodegenerative disease progression. White matter hyperintensities (WMH), a marker of small vessel disease, are influenced by cardiovascular ...
Altschuler F, Canziani V, Ibanez A, Medel V, Campo C.   +4 more
europepmc   +2 more sources

Personalized AI Models for Accelerated Aging [PDF]

Alzheimers Dement
Abstract Background The current understanding of brain aging and dementia diagnostics relies heavily on standardized data from homogeneous populations in the Global North, which creates challenges in assessing diverse populations. Critical gaps exist in understanding how geographical, socioeconomic, and demographic factors impact accelerated brain ...
Moguilner S, Baez S, Hernandez H, Legaz A, Whelan R, Ibanez A.   +5 more
europepmc   +2 more sources