Results 151 to 160 of about 1,290,184 (308)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Endogenous Monetary Policy Regime Change [PDF]
This paper makes changes in monetary policy rules (or regimes) endogenous. Changes are triggered when certain endogenous variables cross specified thresholds.
Troy Davig, Eric M. Leeper
core
Angstrom-Scale Confinement Activates O2 via Spin and Charge Reconfiguration. [PDF]
J Phys Chem LettBu C, Huang L, Wang J.
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Exchange Rate Regime Transition Dynamics In East Asia [PDF]
This paper investigates the currency regime choices of six East Asian emerging countries, namely, Indonesia, Korea, Malaysia, Philippines, Singapore and Thailand, for the period 1973-99 from the optimum currency area (OCA), macroeconomic stabilization ...
Monzur Hossain
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Comment on Benjamin Smith (2004): “Oil Wealth and Regime Survival in the Developing World, 1960-1999” [PDF]
In “Oil Wealth and Regime Survival in the Developing World, 1960-1999“ Benjamin Smith examines the effects of oil wealth, as well as of sudden changes in oil prices, on regime failure, political protest and civil war. He finds that oil wealth is robustly
Hlavac, Marek
core
Culture regime as an experimental variable in <i>Caenorhabditis elegans</i>: Cross-format evidence, reproducibility constraints, and proposed minimum reporting framework. [PDF]
Biol Methods ProtocDinc B +5 more
europepmc +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source