Results 71 to 80 of about 201,237 (217)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Reciprocal Influence of the Countries Appealing to the Resource Nationalism Policy
Halyk̦aralyk̦ k̦atynastar ža̋ne halyk̦aralyk̦ k̦u̇k̦yk̦ seriâsì, 2016 This paper examines the cases of resource nationalism policies in such oil producing countries as Iran, Iraq, Libya, Mexico, Venezuela, and Saudi Arabia.
М. С. Мукан
doaj
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Political Connections, Investment Efficiency, And the Regime Change in Malaysia
Gadjah Mada International Journal of BusinessPurpose – This study examines how Malaysia’s 2018 political regime change affected investment efficiency among politically connected firms (PCFs). Design/methodology/approach – Treating the transition as a quasi-natural experiment, the study applies a ...
Kang Wan Tan, Mei Foong Wong
doaj
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Preemptive multipartism and democratic transitions
Political Science Research and MethodsScholars debate whether the presence of multiple parties in the legislature stabilizes dictatorships or promotes their demise. We show that authoritarian regimes face a dilemma: allowing for multipartism reduces the risk of bottom-up revolt, but ...
Natán Skigin, Aníbal Pérez-Liñán
doaj +1 more source
News and Syria: Creating key media moments in the conflict
Cogent Social Sciences, 2016 Mass media play a critical role through the production of news in influencing how citizens have their perceptions and opinions shaped. This article intends to delve into the role of news production in creating knowledge and shaping public perception and ...
Greg Simons
doaj +1 more source