Results 41 to 50 of about 922 (191)

Dynamischer Austausch von Bindemolekülen steigert die Effizienz der Proteinmarkierung in DNA‐PAINT um das bis zu 15‐Fache

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
Der dynamische Austausch von Bindemolekülen (Dynamic Binder Exchange; DyBE) nutzt transiente Binde–Zielprotein‐Interaktionen, um die Markierungseffizienz in der superauflösenden Mikroskopie um das 15‐Fache zu steigern. DyBE kartiert die Organisation von Rezeptor‐Tyrosinkinasen (RTKs), einschließlich HER2‐Homodimere und EGFR–HER2‐Heterodimere, auf der ...
Clemens Steinek, Isabelle Pachmayr, Sebastian Strauss, Monique Honsa, Jisoo Kwon, Ralf Jungmann   +5 more
wiley   +1 more source

Pathwise Sensitivity Analysis in Transient Regimes [PDF]

, 2015
The instantaneous relative entropy (IRE) and the corresponding instanta- neous Fisher information matrix (IFIM) for transient stochastic processes are pre- sented in this paper. These novel tools for sensitivity analysis of stochastic models serve as an extension of the well known relative entropy rate (RER) and the corre- sponding Fisher information ...
Arampatzis, Georgios, Katsoulakis, Markos, Pantazis, Yannis   +2 more
openaire   +2 more sources

Real‐world evidence of tirbanibulin in the treatment of actinic keratosis in Germany – prospective, multicenter, non‐interventional KLIR study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 2, Page 186-193, February 2026.
Summary Background Tirbanibulin is an approved topical treatment for actinic keratosis (AK). This non‐interventional study investigated effectiveness and safety of tirbanibulin for AK. Patients and Methods The prospective KLIR‐study was conducted at 58 German dermatology centers (02/2022–09/2023).
Markus V. Heppt, Ina Hadshiew, Afra Kempf, Antje Melzer, Carola Berking   +4 more
wiley   +1 more source

Fluoreszenzmarkierte Peptidtracer zur simultanen Aktivierung und Bildgebung des Oxytocinrezeptors

Angewandte Chemie, Volume 137, Issue 46, November 10, 2025.
Licht ins Dunkel: Hier präsentieren wir die Entwicklung fluoreszenzmarkierter Peptid‐Tracer, die eine gleichzeitige Visualisierung und Aktivierung des Oxytocinrezeptors – eines G‐Protein‐gekoppelten Rezeptors, der an Gesundheit und Krankheit beteiligt ist – ermöglichen.
Monika Perisic Böhm, Predrag Kalaba, Rachel S. Gormal, Maja Zupančič, Alexandra Wolf, Mia Juračić, Thomas Kremsmayr, Frédéric A. Meunier, Thierry Langer, Christian W. Gruber, Erik Keimpema, Markus Muttenthaler   +11 more
wiley   +1 more source

Monolagen‐Spezifische Struktur und Dynamik von Oberflächen‐ und Polymer‐Gestützten Lipiddoppelschichten

Angewandte Chemie, Volume 137, Issue 21, May 19, 2025.
Das Manuskript untersucht die strukturellen und dynamischen Eigenschaften von Polyethylenglykol‐gestützten Lipiddoppelschichten unter Verwendung einer Methode, die auf Graphen‐induziertem Energietransfer und Line‐Scan‐Fluoreszenz‐Lebenszeit‐Korrelationsspektroskopie basiert. Diese Technik ermöglicht eine subnanometer‐genaue räumliche Auflösung und eine
Narain Karedla, Falk Schneider, Jörg Enderlein, Tao Chen   +3 more
wiley   +1 more source

MODELAGEM MATEMÁTICA DE FLUXO EM REGIME TRANSIENTE DO SISTEMA HIDROGEOLÓGICO DA BACIA SEDIMENTAR DE RESENDE – RJ.

Revista Águas Subterrâneas, 2010
A região da Bacia Sedimentar de Resende, na região do Vale do Paraíba do Sul Fluminense, sofre um desenvolvimento econômico e populacional acelerado, com aumento da demanda pelo abastecimento de água.
Felipe Abrahão Monteiro, Thayla Almeida Teixeira Vieira, Cynthia Augusto Gonçalves Silva, Gerson Cardoso da Silva Júnior   +3 more
doaj  

Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine‐Induced Cachexia

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 2, April 2025.
Abstract Background Cachexia is a severe form of muscle wasting disorder particularly observed in patients with advanced cancer. The absence of effective strategies to ameliorate cachexia indicates our poor understanding of the mechanisms of cachexia. By employing system‐wide approaches, we investigated molecular mechanisms underlying cancer secreted ...
Luis Vincens Gand, Chiara Lanzuolo, Mugeng Li, Valentina Rosti, Natalie Weber, Dongchao Lu, Christian Bär, Thomas Thum, Andreas Pich, Theresia Kraft, Mamta Amrute‐Nayak, Arnab Nayak   +11 more
wiley   +1 more source

Análise de transferência de calor em regime transiente em materiais anisotrópicos aplicando o MEC [PDF]

, 2014
Dissertação (mestrado)—Universidade de Brasília, Departamento de Engenharia Mecânica, 2014.O trabalho apresenta um estudo sobre condutividade térmica efetiva de um meio poroso em regime transiente de transferência de calor.
Pestana, Miélle Silva
core  

Physiological role of potassium channels in mammalian germ cell differentiation, maturation, and capacitation

Andrology, Volume 13, Issue 2, Page 184-201, February 2025.
Abstract Background Ion channels are essential for differentiation and maturation of germ cells, and even for fertilization in mammals. Different types of potassium channels have been identified, which are grouped into voltage‐gated channels (Kv), ligand‐gated channels (Kligand), inwardly rectifying channels (Kir), and tandem pore domain channels (K2P).
Ariadna Delgado‐Bermúdez, Marc Yeste, Sergi Bonet, Elisabeth Pinart   +3 more
wiley   +1 more source

Métodos de redução de base para problemas térmicos em regime transiente com condições de contorno de radiação e convecção [PDF]

, 1991
ln the past few years there have been a renewed interest in reduction methods for transient heat transfer analysis. Particularly, for transient heat conduction, it has been shown that reduction methods based on Lanczos-type algorithms or Ritz methods are
Santos, Fernando Carvalho dos
core