Results 51 to 60 of about 1,270,000 (363)

Comparison of bortezomib-cyclophosphamide-dexamethasone versus bortezomib-dexamethasone based regimens in newly diagnosed multiple myeloma patients

Hematology Reports, 2020
The treatment landscape and clinical outcome of multiple myeloma (MM) patients have changed in the last decades, with an improved median survival of 8-10 years. This study aimed to evaluate the bortezomib, cyclophosphamide and dexamethasone (VCD) regimen
Rafiye Ciftciler, Hakan Goker, Yahya Buyukasik, Nilgun Sayınalp, Ibrahim C. Haznedaroglu, Salih Aksu, Osman Ozcebe, Haluk Demiroglu   +7 more
doaj   +1 more source

Randomized multicenter phase III study of a modified docetaxel and cisplatin plus fluorouracil regimen compared with cisplatin and fluorouracil as first-line therapy for advanced or locally recurrent gastric cancer

Gastric Cancer, 2015
BackgroundThe V325 study showed that docetaxel, cisplatin, and fluorouracil (DCF) prolonged overall survival (OS) of patients with advanced gastric cancer, but with a high incidence of dose-limiting toxicities.
Jinwan Wang, R. Xu, Jian Li, Y. Bai, Tianshu Liu, S. Jiao, G. Dai, Jianming Xu, Yunpeng Liu, N. Fan, Y. Shu, Y. Ba, D. Ma, S. Qin, Leizhen Zheng, Weichang Chen, L. Shen   +16 more
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Behavioral Model of Middle-Aged and Seniors for Bicycle Tourism

Frontiers in Psychology, 2020
This research centers on the behavioral tendency of the middle-aged and seniors in bicycle tourism at environmentally protected scenic areas and its relevant influence factors.
Shu-Wang Lin, Shih-Yun Hsu, Juei-Ling Ho, Mei-Ying Lai   +3 more
doaj   +1 more source

Dosage regimen design

Pharmacology & Therapeutics, 1982
Pharmacology and Therapeutics 17 (1982) 143-163. doi:10.1016/0163-7258(82)90009-2 ; Received by publisher: 0000-01-01 ; Harvest Date: 2016-01-04 12:21:19 ; DOI:10.1016/0163-7258(82)90009-2 ; Page Range: 143 ...
Division of Clinical Pharmacokinetics, College of Pharmacy, University of Florida, Gainesville, FL 32610, U.S.A. ( host institution ), Lindsay DeVane, C. ( author ), Jusko, William J. ( author )   +2 more
openaire   +4 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

What Is the Cost of Weight Loss? An Approach to Commercial (Dry and Wet) and Homemade Diets

Animals
In the context of the rising prevalence of obesity among pets, this study aimed to assess the economic aspects of weight reduction protocols for dogs and cats, considering the lack of information and the varying costs of commercial and homemade diets ...
Thiago Henrique Annibale Vendramini, Henrique Tobaro Macedo, Andressa Rodrigues Amaral, Rafael Vessecchi Amorim Zafalon, Adrielly Aparecida do Carmo, Cinthia Gonçalves Lenz Cesar, Pedro Henrique Marchi, Júlio Cesar de Carvalho Balieiro, Marcio Antonio Brunetto   +8 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Comparing the Daily Versus the Intermittent Regimens of the Anti-Tubercular Chemotherapy in the Initial Intensive Phase in Non-HIV, Sputum Positive, Pulmonary Tuberculosis Patients [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Tuberculosis (TB) is a major health problem in the universe and India is no longer exempted from this crisis. The emergence of HIV and MDRTB (Multi Drug Resistant Tuberculosis) have further made the situation critical. Aims: Our aim was to
Pranab Kumar Mandal, Abhijit Mandal, Sujit Kumar Bhattacharyya   +2 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source