Results 71 to 80 of about 728,324 (311)

Lactate-Induced Mitochondrial Calcium Uptake 3 Aggravates Myocardial Ischemia–Reperfusion Injury by Promoting Neutrophil Extracellular Trap Formation

Research
Background: Ischemic heart disease is a leading cause of mortality and disability worldwide among cardiovascular conditions. Myocardial ischemia–reperfusion injury (MIRI) occurs following percutaneous coronary intervention, during which neutrophils ...
Hongru Zhang, Lei Liu, Chuchu Shen, Xinxue Jiang, Jing Liu, Jing Chen, Senlei Xu, Yanfei Mo   +7 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens [PDF]

, 2008
Mark E. Dudley, James Chih‐Hsin Yang, Richard M. Sherry, Marybeth S. Hughes, Richard E. Royal, Udai S. Kammula, Paul F. Robbins, JianPing Huang, Deborah E. Citrin, Susan F. Leitman, John R. Wunderlich, Nicholas P. Restifo, Armen A. Thomasian, Stephanie G. Downey, Franz O. Smith, Jacob A. Klapper, Kathleen E. Morton, Carolyn M. Laurençot, Donald E. White, Steven A. Rosenberg   +19 more
openalex   +1 more source

Comparison of efficacy from two different dosing regimens of bortezomib: an exposure–response analysis [PDF]

, 2020
Dolly A. Parasrampuria, Jianming He, Liping Zhang, Bogdan Muresan, Peter Hu, Sepideh Nemat, Mahmoud Hashim, Annette Lam, Carlos Appiani, Michèle Cavo, Meletios Α. Dimopoulos, Jesús F. San Miguel, María‐Victoria Mateos   +12 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Politics and Medicine. The Problem of Change in Regimen in Acute Diseases and Thucydides (Book 6) [PDF]

, 2012
Jacques Jouanna
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Assesmenf of T.B Patients, Relation between their knowledge of disease and therapeutic regimers in TB/Controlcenter, Tehran, 1377 [PDF]

حیات, 2000
"nThis research is a descriptive- analytic study which has been conducted in"norder to determine the degree of tuberculous patients knowledge of their tubereulosis disease and its relation to therapeutic regimen in Tehran TB control centers ...
P hajamiri, Z Monjamed, F Tabari, N Bahrani   +3 more
doaj   +2 more sources

Therapeutic Effect of Membrane Vesicle Drug Delivery Systems in Inflammatory Bowel Disease

Pharmaceutics
Inflammatory bowel disease (IBD) is a chronic, heterogeneous condition characterized by recurrent intestinal inflammation and sustained mucosal barrier damage, profoundly impairing patients’ quality of life and imposing a considerable socioeconomic ...
Zhe Zhao, Ziyun Li, Yihuang Gu, Renjun Gu   +3 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source