Results 81 to 90 of about 1,270,000 (363)

Lactate-Induced Mitochondrial Calcium Uptake 3 Aggravates Myocardial Ischemia–Reperfusion Injury by Promoting Neutrophil Extracellular Trap Formation

Research
Background: Ischemic heart disease is a leading cause of mortality and disability worldwide among cardiovascular conditions. Myocardial ischemia–reperfusion injury (MIRI) occurs following percutaneous coronary intervention, during which neutrophils ...
Hongru Zhang, Lei Liu, Chuchu Shen, Xinxue Jiang, Jing Liu, Jing Chen, Senlei Xu, Yanfei Mo   +7 more
doaj   +1 more source

Medication regimens [PDF]

Canadian Medical Association Journal, 2012
Jonathan, Fuller, C Shawn, Tracy, Ross E G, Upshur   +2 more
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

On the Portuguese Wave Regimen

Coastal Engineering 1974, 1974
Some general characteristics of the wave regimen along the Portuguese coast and the zones next to it are presented. The paper is of a chiefly informative nature and results from the analysis of values obtained during an initial stage of swell observation, applied to studies carried out at the Laboratorio Nacional de En genharia Civil(LNEC),Lisbon ...
openaire   +3 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Assesmenf of T.B Patients, Relation between their knowledge of disease and therapeutic regimers in TB/Controlcenter, Tehran, 1377 [PDF]

حیات, 2000
"nThis research is a descriptive- analytic study which has been conducted in"norder to determine the degree of tuberculous patients knowledge of their tubereulosis disease and its relation to therapeutic regimen in Tehran TB control centers ...
P hajamiri, Z Monjamed, F Tabari, N Bahrani   +3 more
doaj   +2 more sources

Randomized Study Comparing a Basal-Bolus With a Basal Plus Correction Insulin Regimen for the Hospital Management of Medical and Surgical Patients With Type 2 Diabetes

Diabetes Care, 2013
OBJECTIVE Effective and easily implemented insulin regimens are needed to facilitate hospital glycemic control in general medical and surgical patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS This multicenter trial randomized 375 patients
G. Umpierrez, D. Smiley, K. Hermayer, A. Khan, D. Olson, Christopher Newton, S. Jacobs, M. Rizzo, Limin Peng, David Reyes, Ingrid Pinzon, M. E. Fereira, V. Hunt, Ashwini Gore, M. Toyoshima, V. Fonseca   +15 more
semanticscholar   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Therapeutic Effect of Membrane Vesicle Drug Delivery Systems in Inflammatory Bowel Disease

Pharmaceutics
Inflammatory bowel disease (IBD) is a chronic, heterogeneous condition characterized by recurrent intestinal inflammation and sustained mucosal barrier damage, profoundly impairing patients’ quality of life and imposing a considerable socioeconomic ...
Zhe Zhao, Ziyun Li, Yihuang Gu, Renjun Gu   +3 more
doaj   +1 more source

A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer

Pediatric Blood & Cancer, 2013
Preclinical models show that an antiangiogenic regimen at low‐dose daily (metronomic) dosing may be effective against chemotherapy‐resistant tumors. We undertook a prospective, open‐label, single‐arm, multi‐institutional phase II study to evaluate the ...
N. Robison, F. Campigotto, S. Chi, P. Manley, C. Turner, M. Zimmerman, Christine A. Chordas, Annette M Werger, J. Allen, S. Goldman, J. Rubin, Michael S. Isakoff, Wilbur Pan, Z. Khatib, M. Comito, A. Bendel, Jay B Pietrantonio, L. Kondrat, Shannon M Hubbs, D. Neuberg, M. Kieran   +20 more
semanticscholar   +1 more source