Results 111 to 120 of about 2,053,309 (328)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Quem lidera os governos europeus? A carreira dos primeiros-ministros (1946-2006) Who are the European leaders? The careers of prime ministers (1946-2006)

Análise Social, 2009
Este artigo tem como objectivo perceber quem são os primeiros-ministros europeus, reflectindo ainda sobre a influência que os contextos institucionais e partidários exercem sobre os seus perfis.
Nuno Guedes
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Regime não-linear de trens de ondas modulados na direção transversal em um escoamento de Poiseuille plano [PDF]

, 2008
Homero Ghioti da Silva
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Discussion: “Analysis of Plain Cylindrical Journal Bearings in Turbulent Regime” (Arwas, E. B., Sternlicht, B., and Wernick, R. J., 1964, ASME J. Basic Eng., 86, pp. 387–394) [PDF]

, 1964
R. A. Burton
openalex   +1 more source

Review for "Altered precipitation dynamics lead to a shift in herbivore dynamical regime"

, 2021
Joel G. Kingsolver
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

How do Euro-Atlantic regimes respond to climate change?

, 2022
Joshua Dorrington, Kristian Strømmen, Federico Fabiano, T. N. Palmer   +3 more
openalex   +1 more source

The demand for military expenditure in authoritarian regimes [PDF]

, 2011
We investigate how the influence of the military differs across authoritarian regimes and verify whether there are actually systematic differences in military expenditures amongst different forms of dictatorships.
Bove, Vincenzo, Brauner, Jennifer
core