Results 141 to 150 of about 699,410 (260)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Regime-aware causal Bayesian forecasting for non-stationary time series. [PDF]

PLoS One
Mossop B, Choudhury S.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Parametric and Non-parametric Approaches to Exits from Fixed Exchange Rate Regimes [PDF]

Following the demise of the Bretton-Woods increasing number of countries has been opting for flexible exchange rate regimes. Exiting from fixed regimes however is not without costs.
Ahmet Atil Asici
core  

Potassium Humate and <i>Bacillus aryabhattai</i> Modulate Osmotic and Oxidative Homeostasis and Promote Cowpea Yield Under Drought. [PDF]

Plants (Basel)
Melo EMDC, Oliveira AMF, Bonou SI, Viana PMO, Cavalcante IE, Dias GF, Dantas ACDS, Gonçalves TWDS, Farias ESD, Guimarães JA, Lima LM, Melo AS.   +11 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Economic fundamentals and exchange rates under different exchange rate regimes: Korean experience [PDF]

Korea provides a unique opportunity to study the different behaviors or roles, if any, of limited flexibility and free floating exchange rate regimes.
Byung-Joo Lee
core  

Effects of prescribed burning regimes on soil fungal communities, functional traits, and community assembly processes in surface and subsurface peat. [PDF]

FEMS Microbiol Ecol
Allingham SM, Drake SJ, Ramsey A, Field CD, Nwaishi FC, Elliott DR.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

De facto exchange rate regimes and currency crises : are Pegged regimes with capital account liberalization really more prone to speculative attacks?

, 2008
This paper empirically examines whether de facto exchange rate regimes affect the occurrence of currency crises in 84 countries over the 1980-2001 period by using the probit model.
329, Esaka, Taro
core