Results 81 to 90 of about 170,504,010 (244)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Moving Target Recognition Based on HSV Color Space

Kongzhi Yu Xinxi Jishu, 2020
Extracting of ROI (region of interest) has been widely used in the fields of detecting and tracking moving objects. HSV (hue saturation value) is a color space created according to the visual properties of colors, which can be used to describe colors ...
FU Changfei, YE Bin, LI Huijun
doaj  

INTELLIGENT DETECTION AND CLASSIFICATION OF MICROCALCIFICATION IN COMPRESSED MAMMOGRAM IMAGE

Image Analysis and Stereology, 2015
The main contribution of this article is introducing an intelligent classifier to distinguish between benign and malignant areas of micro-calcification in companded mammogram image which is not proved or addressed elsewhere.
Benjamin Joseph, Baskaran Ramachandran, Priyadharshini Muthukrishnan   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

1st January, 1957 - 31st December, 1957 [PDF]

, 1957
This Report, the Third Annual Report ofthe Eastern Regional Marketing Board, has been prepared in accordance with the requirements of Section 33(1) of the Eastern Regional Marketing Board Law (No.
EASTERN Region of Nigeria
core  

Alignment Detection Technology of Chang’e-6 Primary Package Container

Aerospace
The Chang’e-6 mission achieved the first successful sample collection and return from the Moon’s far side. Accurate alignment detection of the primary packaging container is critical for the success of this mission, as it ensures proper retrieval of ...
Guanyu Wang, Shenyi Jin, Xiangjin Deng, Yufu Qu   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Remote Sensing Image Retrieval Combining Global Features and Correlation-Based Local Features

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Remote sensing image retrieval remains challenging due to cluttered backgrounds, large intra-class variations, high inter-class similarity, small object sizes, and inconsistent scales.
Lili Li, Annan Zhou, Jian Yao
doaj   +1 more source