Results 61 to 70 of about 4,380,277 (248)

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

An examination of models for state and regional land use planning. Working paper - State-Regional Land Use Task Force, University of Illinois ; no. 3 [PDF]

, 1974
Made available in DSpace on 2011-11-21T22:20:15Z (GMT). No. of bitstreams: 2 examinationofmod03univ.pdf: 3244431 bytes, checksum: 0f1dbf83417b54daa0638a441157c526 (MD5) license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) Previous ...
University of Illinois at Urbana-Champaign. State-Regional Land Use Task Force
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Constrained Forest Methane Sink by Thermal Adaptation of Soil Methanotrophs

Advanced Science, EarlyView.
Climate warming can stimulate methanotroph‐mediated CH4 oxidation in forest soils, thereby mitigating the increase in atmospheric CH4 concentrations. By integrating evidence from a macro‐climatic thermal gradient and a 70‐day incubation experiment, this study demonstrates that microbial methanotrophs can adapt to long‐term temperature changes at the ...
Baizhi Jiang, Xi Zhang, Zhenghu Zhou, Nianpeng He, Xuhui Zhou, Hongyang Chen   +5 more
wiley   +1 more source

Surgery-first approach on patients with temporomandibular joint disease by intraoral vertical ramus osteotomy

, 2013
Orthognathic surgery followed by postsurgical orthodontics without presurgical orthodontic treatment, known as the surgery-first approach (SFA), has become favored recently. The advantages of this surgical approach include total treatment time reduction,
박형식, 정영수
core   +1 more source

Supercapacitor Safety: Overcharge‐Induced Failure Mechanisms in Electrochemical Double‐Layer Capacitors

Advanced Science, EarlyView.
Time‐resolved synchrotron radiography reveals the internal evolution of electrochemical double‐layer capacitors under abusive overcharge. EDLCs are shown to follow a thermally driven failure pathway involving electrolyte decomposition, gas generation, and structural collapse, distinct from chemically driven thermal runaway effects of Lithium‐ion ...
Thomas Dore, Inez Kesuma, Abdus S. Ali, Jonas Pfaff, Yuxiao Jin, Rosalie Hamill, Mark Buckwell, Hamish Reid, Thomas Finco, Zeyu Sun, Yuanze Li, Sebastian Schopferer, Siegfried Nau, Nils Böttcher, Henning Markötter, Alexander J. E. Rettie, James Robinson, Paul R. Shearing, Alexander Rack, Thomas S. Miller   +19 more
wiley   +1 more source

Effect of Low-Level Laser Therapy (LLLT) after Piezocision on the Rate of Tooth Movement During En-Masse Retraction: A Prospective Clinical Study

Orthodontic Journal of Nepal
Background: With increasing awareness of facial aesthetics and the desire for an appealing smile, patients are demanding faster and better results than ever before in orthodontic treatment.
Geetika Simhadri, Kala Vani S. V., Madhuri Nadhamuni, Surya Mithra G. V. N.   +3 more
doaj   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Issue analysis as a basis for sub-state regional role delineation. Working paper - State-Regional Land Use Task Force, University of Illinois ; no. 2 [PDF]

, 1974
Made available in DSpace on 2011-11-21T22:17:21Z (GMT). No. of bitstreams: 2 issueanalysisasb02univ.pdf: 4228704 bytes, checksum: 2b79e6ac983c5826394c074300137ea2 (MD5) license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) Previous ...
University of Illinois at Urbana-Champaign. State-Regional Land Use Task Force
core