Results 61 to 70 of about 100,301 (307)

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Safety of Cubital Tunnel Release Under General versus Regional Anesthesia

Local and Regional Anesthesia, 2023
Courtney R Carlson Strother,1 Lauren E Dittman,1 Marco Rizzo,1 Steven L Moran,2 Peter C Rhee1 1Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; 2Department of Plastic Surgery, Mayo Clinic, Rochester, MN, USACorrespondence: Peter C Rhee,
Carlson Strother CR, Dittman LE, Rizzo M, Moran SL, Rhee PC   +4 more
doaj  

Carotid Endarterectomy with Local Anesthesia and LMA/General Anesthesia

ScienceOpen Research, 2014
There is no clear consensus as to the appropriate anesthetic technique for patients undergoing a carotid endarterectomy. Such patients may have comorbid conditions, such as coronary artery disease, hyperlipidemia, and others.
Hani Annabi, Charles Fleischer, Robert Taylor, Steven Gruendling, joe pergolizzi, Adrian Bermudez   +5 more
doaj   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

Effect of Regional Versus Local Anesthesia on Outcomes of Radiocephalic Arteriovenous Fistula Creation for Hemodialysis Access: A Prospective Randomized Study

Kardiyovasküler Tıp E Dergisi/E Journal of Cardiovascular Medicine
Objectives: To investigate the effect of regional versus local anesthesia on perioperative outcomes in patients with end-stage renal disease undergoing radiocephalic arteriovenous fistula for hemodialysis access.
Mustafa Selçuk Atasoy, Hakan Güven, Ahmet Yüksel, Ayhan Müdüroğlu, Demir Çetintaş, Ali Önder Kılıç, Serdar Badem, Mustafa Aldemir, Mustafa Çağdaş Çayır, Murad Kaya, Mustafa İşleyen, Yusuf Velioğlu   +11 more
doaj   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Ultrasound-Guided Regional Anesthesia Tutorial

MedEdPORTAL, 2012
This web-based tutorial was designed to provide a resource for learning about ultrasound-guided regional anesthesia. This project was the result of one resident's desire to have a resource where one could easily find all that is needed to know to prepare
Martha Johnson, Ben Swoboda
doaj   +1 more source

Multimodal anesthesia associated with regional block in a dog who underwent corrective surgery for persistent right aortic arch: case report

, 2022
Larissa de Sant' Ana Alves, Byatriz Christina Soares Benevides, Camila Carneiro Araújo, Ana Karoline Rocha Vieira, Darlla Whaianny Fernandes de Lima, Larissa de Castro Demoner   +5 more
openalex   +2 more sources

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source