Results 101 to 110 of about 3,455,651 (283)

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Autonomy and Performance of Foreign Subsidiaries in five Transition Countries [PDF]

The paper analyses the link between the autonomy according to business function and the performance of foreign subsidiaries in Slovenia, Poland, Hungary, Slovakia and Estonia.
Urmas Varblane, Helena Hannula, Katrin Männik   +2 more
core  

Literature Study on the Appointment of Acting Regional Heads from Active Indonesian National Army (TNI) Elements in Regional Autonomy Perspective [PDF]

This research is a literature study that analyzes the construction of regional autonomy perspectives in the appointment of Acting Regional Heads from the active Indonesian National Army (TNI) based on various academic studies.
Hernadi Affandi, Inna Junaenah, Tanjung, Febriasty   +2 more
core   +1 more source

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

The Implication of Regional Autonomy Policy on Regional Road Development: Case in Banyuwangi Regenc

, 2011
The general objective of the present study is to identify the implication of regional autonomy policy on the utilization of road infrastructure in Banyuwangi Regency.
, Adityo Galih Satria, , Ir. Heru Sutomo, M.Sc.(Eng)., Ph.D.   +1 more
core  

Transformer‐Based PET/CT Fusion Enables Preoperative Prediction and Prognostic Stratification of Spread Through Air Spaces in Lung Adenocarcinoma

Advanced Science, EarlyView.
An eight‐stream 2.5D Transformer integrates complementary PET metabolic and CT morphologic information to estimate spread‐through‐air‐spaces risk before surgery in lung adenocarcinoma. The model generalizes across independent centers, while its continuous risk score independently stratifies progression‐free survival, supporting further prospective ...
Xin‐Yu Zhu, Meng Meng, Zhen‐Zhen Wang, Deng‐Lu Lu, Ya‐Min Wei, Xu‐Chang Mi, Xing‐Yu Mu, Wei Fu   +7 more
wiley   +1 more source

Analisis Dampak Otonomi Daerah Terhadap Pembangunan Manusia (Human Capital) Di Provinsi Gorontalo

, 2012
Every regional proliferation as an attempt in the implementation of regional autonomy is essentially based on the Regional Autonomy Regulation No.32/2004 with the goal to achieve the social welfare.
Adam, Syafryanto
core  

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Regional Autonomy in Nigeria: Influence on Dynamics of Governance and National Integration

Social Sciences
This article analyzes the significance of regional autonomy in Nigeria and its impact on both national integration processes and governance issues, based on the empirical argument for the autonomy of ethnically diverse regions.
Olugbenga James, Sadık Akyar
doaj   +1 more source