Results 171 to 180 of about 591,450 (353)

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Three PtIV prodrugs MRP, DRP, and HRP are designed to induce pyroptosis in low GSDME‐expressing tumor cells via the Caspase‐3/GSDME pathway. By relaxing chromatin and reactivating GSDME, HRP can effectively induce pyroptosis, enhance pro‐inflammatory cytokine production, and exhibit potent antitumor effects.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
wiley   +1 more source

Effects of GIP on regional blood flow during normoglycemia and hyperglycemia in anesthetized rats. [PDF]

Physiol Rep, 2018
Gao X, Lindqvist A, Sandberg M, Groop L, Wierup N, Jansson L.   +5 more
europepmc   +1 more source

EFFECTS OF ATENOLOL ON REGIONAL MYOCARDIAL BLOOD FLOW AND ST SEGMENT ELEVATION IN THE CANINE MYOCARDIUM [PDF]

, 1977
Alain Berdeaux, J R Boissier, J. F. Giudicelli   +2 more
openalex   +1 more source

Adipose Tissue Macrophages as Initiators of Exacerbated Periodontitis in Estrogen‐Deficient Environments via the Amplifier Extracellular Vesicles

Advanced Science, EarlyView.
Chronic systemic inflammation, worsened by estrogen deficiency, underlies and exacerbates periodontitis. Proinflammatory macrophages within visceral adipose tissue are hyperactivated due to hyper‐DNA methylation, releasing small extracellular vesicles (sEVs) similar to those of their parent cells.
Danfeng Li, Tian Yang, Yuqian Li, Xinwei Lyu, Cheng Hu, Jiayin Yan, Jiali Tan   +6 more
wiley   +1 more source

Total and Regional Myocardial Blood Flow Measurements with 25µ, 15µ, 9µ, and Filtered 1-10µ Diameter Microspheres and Antipyrine in Dogs and Sheep [PDF]

, 1974
J. Utley, Edwin L. Carlson, Julien I.E. Hoffman, Hugo M. Martínez, Gerald D. Buckberg   +4 more
openalex   +1 more source

Personalized Neoantigen Vaccine plus Regorafenib Increases Rgs2⁺CD8⁺ T Cells Infiltration and Reprograms the Tumor Microenvironment in Microsatellite Stable Colorectal Cancer Liver Metastases

Advanced Science, EarlyView.
This study synthesized a personalized neoantigen vaccine (Neo‐CRCVAS) and combined it with regorafenib, termed RegoNeo. This combination therapy significantly enhanced antitumor efficacy and promoted long‐term tumor‐specific immune memory in microsatellite stable colorectal cancer liver metastasis (MSS‐CRLM) models by increasing neoantigen‐specific ...
Hengkai Chen, Bin Chen, Yuanfeng Yang, Shoufeng Li, Huajun Cai, Zhicheng Zhuang, Yong Wu, Yuan Gao, Yupeng Chen, Xing Liu, Guoxian Guan, Jinfu Zhuang   +11 more
wiley   +1 more source

Brain Regional Blood Flow and Working Memory Performance Predict Change in Blood Pressure Over 2 Years. [PDF]

Hypertension, 2017
Jennings JR, Heim AF, Sheu LK, Muldoon MF, Ryan C, Gach HM, Schirda C, Gianaros PJ.   +7 more
europepmc   +1 more source

Regional myocardial blood flow during acute myocardial infarction in the conscious dog. [PDF]

, 1976
Sanford P. Bishop, F. C. White, Colin M. Bloor   +2 more
openalex   +1 more source

Advanced Brain‐on‐a‐Chip for Wetware Computing: A Review

Advanced Science, EarlyView.
Exploring Low‐Power, Beyond‐Silicon‐Computing Bio‐Computing: Brain‐on‐a‐Chip Technology. This article reviews the applications of Brain‐on‐a‐Chip in Wetware Computing, including in vitro‐cultured brain organoids, microelectrode arrays, electrophysiological interfaces, and microfluidic platforms, as well as data processing methods. It also looks forward
Shangchen Li, Yaoyao Liu, Sihan Hua, Yu Wang, Shutong Sun, Longhui Jiang, Chengji Lu, Juntao Liu, Huaizhang Shi, Pei Wu, Xinxia Cai, Jinping Luo   +11 more
wiley   +1 more source

Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer's disease. [PDF]

Neuropsychiatr Dis Treat, 2015
Moretti DV.
europepmc   +1 more source