Results 171 to 180 of about 8,322,786 (291)

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Delayed Treatment with Sodium Hydrosulfide Improves Regional Blood Flow and Alleviates Cecal Ligation and Puncture (CLP)-Induced Septic Shock. [PDF]

Shock, 2016
Ahmad A, Druzhyna N, Szabo C.
europepmc   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source

Massive Left Atrial Thrombosis Shortly After Radiofrequency Catheter Ablation: Implications of Reduced Flow Dynamics Detected by Four-Dimensional Flow Magnetic Resonance Imaging. [PDF]

J Arrhythm
Egashira K, Yamasaki H, Kino T, Sato K, Ishizu T.   +4 more
europepmc   +1 more source

XChrom: A Cross‐Cell Chromatin Accessibility Prediction Model Integrating Genomic Sequence and Cellular Context

Advanced Science, EarlyView.
XChrom is a deep learning framework that integrates genomic sequence and single‐cell context to predict chromatin accessibility. It generalizes to unseen cells and genomic regions, enabling cross‐sample and cross‐species analysis. Applied to COVID‐19 patient data, XChrom reveals key transcriptional regulatory mechanisms and disease‐associated ...
Yuanyuan Miao, Xuan Liang, Wenwen Zhang, Dongmei Han, Yurun Li, Zhen Wang   +5 more
wiley   +1 more source

Molecular MRI Reveals Macrophage‐Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer

Advanced Science, EarlyView.
Incomplete microwave ablation (iMWA) induced a spatially organized, macrophage‐rich immunosuppressive tumor microenvironment (TME) in orthotopic VX2 liver tumors. Molecular MRI enhanced with europium‐doped very small superparamagnetic iron oxide nanoparticles (Eu‐VSOP) noninvasively visualized this remodeling, showing preferential nanoparticle ...
Yubei He, Han Xu, Julian M. M. Rogasch, Nikolaus Berndt, Jing Guo, Eyk Schellenberger, Akvile Häckel, Luisa Heidemann, Friederike Hesse, Yu Liu, Justus Ramtke, Nicola Beindorff, Frank Hofheinz, Avan Kader, Michael Mülleder, Kathrin Textoris‐Taube, Bernd Hamm, Dominik N. Müller, Robin Schmidt, Ralf Hauptmann, Heike Traub, Mathias Schannor, Lynn Jeanette Savic   +22 more
wiley   +1 more source

Frontal Cerebral Blood Flow Deficits in Behavioral Variant Frontotemporal Dementia: Associations With Clinical Symptoms, Peripheral Vascular Biomarkers, and Neuroimaging Measures. [PDF]

CNS Neurosci Ther
Hou J, He Q, Fu X, Chen Y, Lu H, Xu Y, Wu L, Chu M.   +7 more
europepmc   +1 more source

Deciphering Intricacies in Directional CO2 Conversion From Electrolysis to CO2 Batteries

Advanced Energy Materials, EarlyView.
This review will delve into the inherent connections and distinctions of CO2‐directed conversion in ECO2RR and CO2 batteries, in terms of product types, catalyst selection, catalytic mechanisms, and electrochemical performances, while proposing a benchmarking framework for the evaluation of CO2 batteries and innovative CO2 battery configurations for ...
Changfan Xu, Huaping Zhao, Lizhuang Chen, Weidong Shi, Guosheng Shao, Yong Lei   +5 more
wiley   +1 more source