Results 91 to 100 of about 4,645,562 (304)

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

A regional, multi-sectoral and integrated assessment of the impacts of climate and socio-economic change in the UK: Part I. Methodology [PDF]

, 2005
Policy makers and stakeholders are increasingly demanding impact assessments which produce policy-relevant guidance on the local impacts of global climate change.
Berry, PM, Harrison, P.A., Holman, Ian P., Rounsevell, M.D.A., Audsley, E., Rounsevell, M, Harrison, PA, Rounsevell, M. D. A., Nicholls, RJ, Nicholls, R. J., Holman, I, Harrison, P. A., Berry, P, Shackley, Simon, Audsley, Eric, Holman, IP, Berry, P. M., Holman, I.P., Nicholls, R.J., Rounsevell, MDA, Berry, P.M., Shackley, S., Harrison, P, Nicholls, R, Rounsevell, Mark, Holman, I. P.   +25 more
core   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Evaluating heat stress and occupational risks in the Southern Himalayas under current and future climates

npj Climate and Atmospheric Science
The southern Himalayas, characterized by its dense population and hot, humid summers, are confronted with some of the world’s most severe heat stress risks. This study uses the hourly ERA5 dataset (1979–2022) and CMIP6 projections (2005–2100) to evaluate
Xiaoye Yang, Cheng Shen, Irfan Ullah, Julia Curio, Deliang Chen   +4 more
doaj   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

Advanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du, Zhixiang Niu, Yanfen Wang, Shirui Zhou, Youqing Yang, Xiang Wei, Haishan Niu, Yitao Zhang, Anquan Xia, Yali Liu, Yanbin Hao, Kai Xue, Bingfang Wu, Xinquan Zhao, Tandong Yao, Yiyu Chen   +15 more
wiley   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Internal Climate Variability in Global and Regional Climate Models

, 2004
Internally generated climate variability on decadal to centennial time scales was studied with a hierarchy of climate models, including global as well as regional models. The analyses of long-term model integrations over 1000 years with global models of different complexity showed their potential to generate interannual to interdecadal variability ...
Handorf, D, Dorn, W, Dethloff, K, Rinke, A, Weisheimer, A   +4 more
openaire   +2 more sources

2014 San Diego Regional Climate Collaborative Annual Report [PDF]

, 2015
The San Diego Regional Climate Collaborative is a network for public agencies that serves the San Diego region to share expertise, leverage resources and advance comprehensive solutions to facilitate climate change planning.
San Diego Regional Climate Collaborative
core  

Editorial Urban and Regional responses to Climate Emergency

, 2020
ities and urban regions are now regularly recognized within international processes on issues such as social inequality, economic marginalization, and climate change.
Da Silva Oliveira, Eduardo Henrique, Julie Tiao Miao, Michael Taster   +2 more
core   +1 more source