Results 111 to 120 of about 847,676 (284)

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Can a regional climate model reproduce observed extreme temperatures?

Statistica, 2013
Using output from a regional Swedish climate model and observations from the Swedish synoptic observational network, we compare seasonal minimum temperatures from model output and observations using marginal extreme value modeling techniques.
Peter F. Craigmile, Peter Guttorp
doaj   +1 more source

A coupled regional climate-biosphere model for climate studies [PDF]

, 1996
This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The objective of this project has been to develop and test a regional climate modeling system that couples a limited-area atmospheric code to a biosphere scheme that properly represents surface processes ...
Bossert, J., Winterkamp, J., Barnes, F., Roads, J.   +3 more
openaire   +2 more sources

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

Projecting regional climate and cropland changes using a linked biogeophysical‐socioeconomic modeling framework: 1. Model description and an equilibrium application over West Africa

Journal of Advances in Modeling Earth Systems, 2017
Agricultural land use alters regional climate through modifying the surface mass, energy, and momentum fluxes; climate influences agricultural land use through their impact on crop yields.
Guiling Wang, Kazi Farzan Ahmed, Liangzhi You, Miao Yu, Jeremy Pal, Zhenming Ji   +5 more
doaj   +1 more source

Universal Solvent Escape Strategies for Efficient Curing of Hydrogen‐Bond‐Rich 3D Printing Inks

Advanced Science, EarlyView.
This study developed a new 3D printing method for hydrogen‐bonded polymers by combining solvent replacement, nanoparticles, and optimized printing paths. This allows fast, precise scaffold fabrication. The scaffolds can be easily customized and release therapeutic agents slowly through protonation, enabling personalized bone, blood vessel, and nerve ...
Jie Chen, Qing Zhao, Wentao Fu, Weixian Chen, Xiaoqian Zhang, Gaiying Ye, Qinglei Meng, Liyuan Shao, Qian Ma, Lin Zhao, Ying Zhao, Weihua Guo   +11 more
wiley   +1 more source

Modelling Regional Climate Change in Germany

, 2011
A series of regional climate simulations using the regional climate model COSMO-CLM (CCLM) have been carried out at the Institute for Meteorology and Climate Research (IMK) of Karlsruhe Institute of Technology (KIT) (Panitz et al. 2010). These simulations span the years 1971–2000 to represent the climate of the recent past and the years 2011–2040 to ...
Berg, P., Panitz, H.-J., Schädler, G., Feldmann, H., Kottmeier, Ch.   +4 more
openaire   +2 more sources

Stress‐Induced Melting Controlled Failure Mechanisms of Methane Hydrate

Advanced Science, EarlyView.
We study methane hydrate via nanoindentation and nuclear magnetic resonance (NMR), finding its regional melting and mechanical properties, challenging existing views on hydrogen‐bonded crystals. Abstract Methane hydrate, a kind of nonstoichiometric crystalline, attracted worldwide attentions as a promising substitute energy. Its Dissociation is thought
Yanlong Li, Yuan Zhou, Zhengcai Zhang, Minhui Qi, Yajuan Zhang, Yujing Jiang, Yunkai Ji, Qingguo Meng, Yongfu Sun, Nengyou Wu   +9 more
wiley   +1 more source

Microgel‐Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction

Advanced Science, EarlyView.
This study develops a hierarchically porous hydrogel patch strategy (HPMP), based on gas‐shearing microfluidics and an aqueous two‐phase system to fabricate porous microgels as microgel‐based bioinks. The porous microgels with controllable porous structure exhibit excellent cellular behavior.
Ziyang Liu, Leyan Xuan, Yingying Hou, Ting Xie, Jieting Li, Junjie Cai, Siyu Zhang, Yingling Miao, Ning Hou, Gen He, Maobin Xie, Xiyong Yu, Mingen Xu, Guosheng Tang   +13 more
wiley   +1 more source

Decadal and multi-year predictability of the West African monsoon and the role of dynamical downscaling

Meteorologische Zeitschrift, 2017
West African summer monsoon precipitation is characterized by distinct decadal variability. Due to its well-documented link to oceanic boundary conditions in various ocean basins it represents a paradigm for decadal predictability.
Heiko Paeth, Andreas Paxian, Dmitry V. Sein, Daniela Jacob, Hans-Jürgen Panitz, Michael Warscher, Andreas H. Fink, Harald Kunstmann, Marcus Breil, Thomas Engel, Andreas Krause, Julian Toedter, Bodo Ahrens   +12 more
doaj   +1 more source