Results 31 to 40 of about 921,239 (238)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Role of National and Regional Road Networks in the Classification of Administrative Centers: A Case Study of Beni Suef and Minya Governorates دور شبكات الطرق القومية والإقليمية في تصنيف المراكز الإدارية: دراسة حالة محافظة (بني سويف – المنيا) [PDF]

Journal of Urban Research
The Upper Nile Valley, particularly the sector between Beni Suef and Minya, has experienced notable spatial and urban changes in recent decades, largely driven by the expansion of national and regional road networks.
Mohamed Abd ELHAKIM Elsayed mohamed, Ebtehal Ahmed Abdalmoity, Muhammad Abdulrahman Seddeek   +2 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Khapra beetle diagnostics

Julius-Kühn-Archiv, 2018
The khapra beetle, Trogoderma granarium Everts, is a serious pest of grains and stored dry food stuffs and is the subject of strict quarantine measures in many countries including Australia.
Byrne, Oonagh, Hair, Sam, Guthrie, Nadine, Farmer, Kira, Szito, Andras, Emery, Robert N.   +5 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Peran sistem informasi geografis dalam pemetaan pandemi: studi kasus Kecamatan Banjarsari, Kota Surakarta

Region: Jurnal Pembangunan Wilayah dan Perencanaan Partisipatif, 2023
Pandemi Covid-19 telah menjadi tantangan berat bagi Indonesia yang merupakan salah satu negara dengan jumlah kasus terkomfirmasi positif yang sangat tinggi. Pulau Jawa merupakan episentrum pandemi Covid-19 di Indonesia.
Murtanti Jani Rahayu, Paramita Rahayu, Rufia Andisetyana Putri, Erma Fitria Rini   +3 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Entrepreneurship and regional development [PDF]

, 2009
This chapter offers a review on modern entrepreneurship analysis, against the background of regional development. After a conceptual discussion on the importance and the measurement of entrepreneurship, the contribution discusses success factors and determinants of entrepreneurships.
Fischer, M.M., Nijkamp, P.
openaire   +3 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Urban Sprawl Characteristics and Typologies in Romania [PDF]

Human Geographies: Journal of Studies and Research in Human Geography, 2010
Urban sprawl limitation, moderate use of agricultural fields and ensuring the social mix are objectives of public policy of all European Community documents refering to urban and territorial planning, housing policies and territorial cohesion.
Bogdan Suditu, Anca Ginavar, Ana Muică, Crenguţa Iordăchescu, Amalia Vârdol, Bogdan Ghinea   +5 more
doaj