Results 41 to 50 of about 17,353,001 (257)

ON EXPECTATIONS AND FRUSTRATIONS: AN INTERPRETATION OF THE GOVERNANCE OF THE AMAZON REGIONAL DEVELOPMENT PLAN

Revista Tempo do Mundo, 2022
The issue of regional inequalities is historical and has structural roots in Brazil. Since the 20th century, regional development policies have changed their visibility on the government’s agenda.
João Mendes da Rocha Neto
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

NORTH CAUCASUS: REGIONAL INSTITUTIONS OF STATE POWER AND THE INTERACTION WITH CIVIL SOCIETY

Современная наука и инновации, 2022
The article discusses the features of the interaction of regional institutionss and civil society in the North Caucasus. Particular attention is paid to regional authorities in the task, including the development of civil society.
Vladimir Vladimirovich Bondar
doaj  

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

On results of the International forum «Arctic-territory of dialogue» [PDF]

Научно-аналитический вестник Института Европы РАН, 2019
On April 9 and 10, 2019, the Fifth international forum «Arctic – territory of dialogue» was held in St. Petersburg. Russian and international experts, representatives of Federal agencies and regional authorities, Russian and foreign companies discussed ...
Valery Zhuravel
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Regionale Leitbilder

Raumforschung und Raumordnung, 1999
Regional visions — or leitbilder — mark out an orientational framework for working towards the desired state of development. Development visions for the region pick up key elements of the regional plan, which they then build upon from a ...
Ekkehard Hein
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Küreselleşme ve Yerelleşme Sürecinde Bölgesel Kalkınma Ajansları

Selçuk Üniversitesi Sosyal Bilimler Meslek Yüksekokulu Dergisi, 2017
Küreselleşmeyle beraber pek çok alanda değişim ve dönüşümler meydana gelmiş, merkezi ve yerel yönetimlerde bu değişim dönüşümlerden nasibini almıştır. Merkezi yönetimlerin yapılarında bir zayıflama görülürken, yerel yönetimler de ise ortaya çıkan değişim
Mahmut Umut Ferman Akbulut, Mehmet Göküş   +1 more
doaj  

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source