Results 221 to 230 of about 1,283,135 (288)

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Regional coordination can alleviate the cost burden of a low-carbon electricity system. [PDF]

Nat Commun
Wessel J, Chowdhury AK, Wild T, Kanyako F, Iyer G, Lamontagne J.   +5 more
europepmc   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

EO-based long term cropland and paddy monitoring with the farm action toolkit (FAcT): strengthening policy support in Bhutan. [PDF]

Discov Agric
Phalke AR, Cox SE, Limaye AS, Dorji R, Phuntsho L, Wangchen T, Rai M, Tshering C, Anderson ER, Nakalembe CL, Mayer TJ, Griffin R.   +11 more
europepmc   +1 more source

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

Advanced Science, EarlyView.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong, Yanhong Liu, Yuanming Liu, Shuxin Xuan, Huanhuan Chen, Lai Wei, Guibao Zhang, Hongcui Pei, Zilong Dai, Yanhua Wang, Jinzhu Qiao, Shuangxia Luo, Xueping Chen, Yiguo Hong, Jianjun Zhao, Shuxing Shen, Zefu Lu, Aixia Gu   +17 more
wiley   +1 more source

Doctors in the making, or degrees for sale? A student's view of Brazil's medical education crisis. [PDF]

Front Med (Lausanne)
Campos VMS, Maggitti-Bezerril M, Menezes RC, Sobral L, Avena KM, Andrade BB.   +5 more
europepmc   +1 more source

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

Exploring barriers to expanding medical training numbers in England: A national survey of medical education directors. [PDF]

Clin Med (Lond)
Batavanis M, Arora A, Aryee S, Nathwani N.   +3 more
europepmc   +1 more source

A Linearly Deformable Pneumatic Scalable Microgripper for Universal Mid‐Air Micromanipulation

Advanced Science, EarlyView.
This work presents a fully 3D printed soft microgripper capable of active adhesion control through a pneumatic system. Its modular design can reach a high adhesion switching ratio of 373 and free release of micro‐objects at 100 μm$\umu \rm {m}$ dimension.
Jiawei Yi, Wissem Haouas, Gwenn Ulliac, Kanty Rabenorosoa   +3 more
wiley   +1 more source