Results 51 to 60 of about 1,283,135 (288)

The Spatiotemporal Pattern of Urban Expansion in China: A Comparison Study of Three Urban Megaregions

open access: yesRemote Sensing, 2017
Urban megaregions have emerged as a new urbanized form. However, previous studies mostly focused on urban expansion at the city scale, particularly for large cities.
Wenjuan Yu, Weiqi Zhou
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

PERAN ELITE POLITIK LOKAL DALAM UPAYA MENDUKUNG PEMEKARAN KABUPATEN PANTAR PROVINSI NTT

open access: yesPolitika: Jurnal Ilmu Politik, 2016
To establish New Autonomous Region, the roles of local political elites are very strong so that expansion policy can be realized. If we look at the dynamics of regional expansion in Indonesia, it has a noble motivation for the welfare of society, but the
Welhelmina Selfina Beli
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

The Expansion of H II Regions

open access: yesThe Astrophysical Journal, 1968
H II regions expansion around O, B and A stars due to interstellar hydrogen ionization by stellar radiation ...
R. C. Newman, W. I. Axford
openaire   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Reconciling diverse lacustrine and terrestrial system response to penultimate deglacial warming in southern Europe [PDF]

open access: yes, 2015
Unlike the most recent deglaciation, the regional expression of climate changes during the penultimate deglaciation remains understudied, even though it led into a period of excess warmth with estimates of global average temperature 1–2 °C, and sea level
Frogley, Michael R   +4 more
core   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Regional sequence expansion or collapse in heterozygous genome assemblies.

open access: yesPLoS Computational Biology, 2020
High levels of heterozygosity present a unique genome assembly challenge and can adversely impact downstream analyses, yet is common in sequencing datasets obtained from non-model organisms.
Kathryn C Asalone   +12 more
doaj   +1 more source

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