Results 51 to 60 of about 221,586 (310)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Remote Sensing, 2017 Urban megaregions have emerged as a new urbanized form. However, previous studies mostly focused on urban expansion at the city scale, particularly for large cities.
Wenjuan Yu, Weiqi Zhou
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
PERAN ELITE POLITIK LOKAL DALAM UPAYA MENDUKUNG PEMEKARAN KABUPATEN PANTAR PROVINSI NTT
Politika: Jurnal Ilmu Politik, 2016 To establish New Autonomous Region, the roles of local political elites are very strong so that expansion policy can be realized. If we look at the dynamics of regional expansion in Indonesia, it has a noble motivation for the welfare of society, but the
Welhelmina Selfina Beli
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Parameterised post-Newtonian expansion in screened regions [PDF]
Journal of Cosmology and Astroparticle Physics, 2017 The parameterised post-Newtonian (PPN) formalism has enabled stringent tests of static weak-field gravity in a theory-independent manner. Here we incorporate screening mechanisms of modified gravity theories into the framework by introducing an effective gravitational coupling and defining the PPN parameters as functions of position. To determine these
McManus, Ryan +2 more
openaire +3 more sources
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Regional sequence expansion or collapse in heterozygous genome assemblies.
PLoS Computational Biology, 2020 High levels of heterozygosity present a unique genome assembly challenge and can adversely impact downstream analyses, yet is common in sequencing datasets obtained from non-model organisms.
Kathryn C Asalone +12 more
doaj +1 more source
Environmental Research Letters, 2023 With the rapid development of urbanization, natural habitats in many parts of the world have been seriously damaged by urban expansion. However, urban expansion is a complex process, and the impacts of different levels of urban expansion on habitats at ...
Shuaipeng Chen, Wenping Liu
doaj +1 more source