Results 151 to 160 of about 1,915,714 (379)

Instituto Mesoamericano de Salud Pública: órgano de apoyo técnico y fortalecimiento del Sistema Mesoamericano de Salud Pública Mesoamerican Public Health Institute: Technical support and capacity strengthening arm of the Mesoamerican Public Health System

open access: yesSalud Pública de México, 2011
OBJETIVO: El Instituto Mesoamericano de Salud Pública (IMSP) se constituyó en 2009 como órgano técnico del Sistema Mesoamericano de Salud Pública (SMSP) y la Red Virtual de Instituciones Académicas.
Miguel A González-Block   +3 more
doaj  

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

open access: yesAdvanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song   +24 more
wiley   +1 more source

Perspectivas de região e redes na política de saúde brasileira

open access: yesSaúde em Debate
Regiões e Redes de Atenção à Saúde são estratégias recentes da política de saúde brasileira. Questiona-se: quais concepções de região e redes de saúde informam a política, como se combinam, em que momentos e com quais objetivos?
Mariana Vercesi de Albuquerque   +1 more
doaj   +1 more source

Mental health plans and policies across the WHO European region

open access: yesCambridge Prisms: Global Mental Health
Abstract Evidence is scarce in terms of tracking the progress of implementation of mental healthcare plans and policies (MHPPs) in Europe, we aimed to map and analyze the content of MHPPs across the WHO European region. We collected data from the WHO Mental Health Atlas 2011, 2017 and 2020 to map the development of MHPPs in the region.
Zoe Guerrero   +10 more
openaire   +3 more sources

In Situ Proliferating Peptide Nanoparticle Augments Multi‐Target Intervention of Secondary Brain Damage Following Subarachnoid Hemorrhage

open access: yesAdvanced Science, EarlyView.
This work designs an in situ proliferating peptide nanoparticle as a flexible resolution that modulates the neuro‐glia unit to enable enhanced multi‐target combinational therapy for secondary brain damage following subarachnoid hemorrhage. Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered ...
Yibin Zhang   +8 more
wiley   +1 more source

Analisis Hierarki Wilayah Dan Interaksi Wilayah Untuk Penentuan Pusat Pelayanan Wilayah Di Kabupaten Lembata Provinsi Nusa Tenggara Timur [PDF]

open access: yes, 2018
Lembata Regency is one of the districts that are categorized as underdeveloped areas and has unique characteristics because it has administrative areas with island characteristics. Spatial structure in the district with characteristics of areas that have
, Drs. Priyono, Pratama, Bruce
core  

Waste indicators of primary sector and health & veterinary services for regional planning [PDF]

open access: bronze, 2014
Eva Cifrián   +4 more
openalex   +1 more source

ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7

open access: yesAdvanced Science, EarlyView.
Histone lysine crotonylation (Kcr) is a highly conserved posttranslational modification implicated with crucial biological processes. This study reveals that ACSS2‐mediated H4K12cr upregulated CLDN7 transcription to strengthen intestinal epithelial barrier.
Ming Yuan   +14 more
wiley   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

open access: yesAdvanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich   +8 more
wiley   +1 more source

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