Results 51 to 60 of about 65,955 (300)

Alterations in Regional Homogeneity in Patients With Unilateral Chronic Tinnitus

Trends in Hearing, 2019
Chronic subjective tinnitus is a widespread disorder. This perceptual anomaly is assumed to result from a dysbalance of excitatory and inhibitory mechanisms on different levels of the auditory pathways.
Anthony Gentil, Jeremy Deverdun, Nicolas Menjot de Champfleur, Jean-Luc Puel, Emmanuelle Le Bars, Frédéric Venail   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The Expenditure Impacts of Individual Higher Education Institutions (HEIS) and their Students on the Welsh Economy : Homogeneity or Heterogeneity? [PDF]

, 2010
This paper replicates the analysis of Scottish HEIs in Hermannsson et al (2010a) for the case of Wales in order to provide a self-contained analysis that is readily accessible by those whose primary concern is with the regional impacts of Welsh HEIs ...
Lisenkova, Katerina, Swales, J Kim, McGregor, Peter, Swales, John, McGregor, Peter G, Hermannsson, Kristinn, Swales, J. Kim, McGregor, Peter G.   +7 more
core  

Dehydration and rehydration affect brain regional density and homogeneity among young male adults, determined via magnetic resonance imaging: A pilot self-control trial

Frontiers in Nutrition, 2022
The effects of dehydration and rehydration on brain regional density and homogeneity are unknown and have been infrequently studied. In this pilot self-control study, twelve participants aged 18-25 years were recruited and the brain was scanned using ...
Na Zhang, Na Zhang, Jianfen Zhang, Jianfen Zhang, Songming Du, Guansheng Ma, Guansheng Ma   +6 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Decreased Regional Homogeneity in Schizophrenia : a Resting State fMRI study [PDF]

, 2006
We used a newly reported regional homogeneity approach to measure the temporal homogeneity of blood oxygen level-dependent signal for exploring the brain activity of schizophrenia in a resting state.
Liu, Zhening, Liang, Meng, Jiang, Tianzi, Tan, Lihua, Kuang, Fan, Liu, Haihong, Xu, Lin, Yi, Yanhong, Hao, Yihui   +8 more
core  

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Flight training and the anterior cingulate cortex

Scientific Reports
Pilots are considered the final line of defense for aviation safety. Before becoming a pilot, an ab initio pilot must undergo systematic flight training. This study included 25 male flying cadets.
Xi Chen, Hongming Wang, Xi Tan, Mingjun Duan, Cheng Luo   +4 more
doaj   +1 more source

Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI study

Frontiers in Human Neuroscience, 2022
ObjectiveStatic regional homogeneity (ReHo) based on the resting-state functional magnetic resonance imaging (rs-fMRI) has been used to study intrinsic brain activity (IBA) in Alzheimer’s disease (AD).
Zhengluan Liao, Zhengluan Liao, Wangdi Sun, Xiaozheng Liu, Zhongwei Guo, Dewang Mao, Enyan Yu, Yan Chen   +7 more
doaj   +1 more source