Results 51 to 60 of about 2,918,181 (287)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Alterations in Regional Homogeneity in Patients With Unilateral Chronic Tinnitus

open access: yesTrends in Hearing, 2019
Chronic subjective tinnitus is a widespread disorder. This perceptual anomaly is assumed to result from a dysbalance of excitatory and inhibitory mechanisms on different levels of the auditory pathways.
Anthony Gentil   +5 more
doaj   +1 more source

Using coherence to measure regional homogeneity of resting-state fMRI signal

open access: yesFrontiers in Systems Neuroscience, 2010
In this study, we applied coherence to voxel-wise measurement of regional homogeneity of resting-state functional magnetic resonance imaging (RS-fMRI) signal.
Dongqiang Liu   +5 more
doaj   +1 more source

Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest

open access: yesFrontiers in Psychiatry, 2021
Background: Gastrointestinal (GI) symptoms are prominent in patients with major depressive disorder (MDD). Previous studies have reported brain structural and functional changes in both MDD and digestive system diseases but it remains unclear whether MDD
Meiqi Yan   +8 more
doaj   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe   +7 more
wiley   +1 more source

Cluster analysis homogeneity statistic

open access: yes, 2018
<p>This is the first release of my code for implementing a homogeneity statistic for cluster analysis results.</p ...
R. Noah Padgett
core   +2 more sources

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin   +8 more
wiley   +1 more source

Midwestern Regional Climate Center [PDF]

open access: yes, 2001
Made available in DSpace on 2016-11-14T22:36:27Z (GMT). No. of bitstreams: 2 ISWSIEM2001-01.pdf: 146176 bytes, checksum: 791a8da476fabb8bec8c3d10ae0a0993 (MD5) license.txt: 3973 bytes, checksum: 6c1c5beee39794d995a5ff442f5bd9ab (MD5) Previous issue ...
Midwestern Regional Climate Center
core  

Perfect imaging in a homogeneous threedimensional region

open access: yesOptics Express, 2006
We introduce a family of spherically symmetric gradient-index lenses forming a perfect (sharp) image of any point of the space in three dimensions, including the points of a homogeneous (constant refractive index) region. The only previously known example of an optical instrument with such properties is the plane mirror (or combinations thereof).
openaire   +2 more sources

Extraction of Homogeneous Regions in Historical Document Images [PDF]

open access: yesProceedings of the 10th International Conference on Computer Vision Theory and Applications, 2015
To reach the objective of ensuring the indexing and retrieval of digitized resources and offering a structured access to large sets of cultural heritage documents, a raising interest to historical document image segmentation has been generated. In fact, there is a real need for automatic algorithms ensuring the identification of homogeneous regions or ...
Maroua Mehri   +5 more
openaire   +1 more source

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