Brain Regional Identity and Cell Type Specificity Landscape of Human Cortical Organoid Models. [PDF]
Int J Mol Sci, 2022 In vitro models of corticogenesis using mouse and human pluripotent stem cells (PSC) have greatly improved our understanding of human brain development and disease.
Magni M +10 more
europepmc +2 more sources
Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming. [PDF]
Sci Adv, 2021 Region-specific gene expression shared with neurons imparts to astrocytes competence for region-specific neuronal reprogramming. Neural cell diversity is essential to endow distinct brain regions with specific functions.
Herrero-Navarro Á +13 more
europepmc +2 more sources
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants.
Cell Stem Cell, 2021 Summary Point mutations within the histone H3.3 are frequent in aggressive childhood brain tumors known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in discrete anatomical regions: H3.3-G34R within the forebrain and H3 ...
Bressan RB +16 more
europepmc +2 more sources
Onomastic Space of Ekaterinburg: Level-Based Markers of Regional Identity [PDF]
Вопросы ономастики, 2023 The paper examines the onomastic space of the city of Ekaterinburg containing regional linguocultural information through the lens of a three-level model of onymic identity markers as “part of the collective regional identity manifested in general ...
Irina T. Vepreva +1 more
doaj +2 more sources
Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging. [PDF]
Cell Rep, 2017 Summary Gene expression studies suggest that aging of the human brain is determined by a complex interplay of molecular events, although both its region- and cell-type-specific consequences remain poorly understood.
Soreq L +11 more
europepmc +2 more sources
The human geography of Twitter: Quantifying regional identity and inter-region communication in England and Wales. [PDF]
PLoS One, 2019 Given the centrality of regions in social movements, politics and public administration, here we aim to quantitatively study regional identity, cross-region communication and sentiment.
Arthur R, Williams HTP.
europepmc +3 more sources
DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development. [PDF]
Gut, 2019 Objective Human intestinal epithelial organoids (IEOs) are increasingly being recognised as a highly promising translational research tool. However, our understanding of their epigenetic molecular characteristics and behaviour in culture remains limited.
Kraiczy J +17 more
europepmc +2 more sources
Belonging and exclusion: the dark side of regional identity in Germany
Comparative European Politics, 2021 A collective regional identity is a favourable condition for the acceptance of majority decisions made at the regional level and for the delegation of competencies from the central to regional governments.
Achim Hildebrandt +2 more
exaly +2 more sources
Unity-in-Diversity?: Regional Identity-building in Southeast Asia
Journal of Current Southeast Asian Affairs, 2010 The aim of this paper is to discuss the issue of regional integration and regional identity-building in Southeast Asia. The idea is to problematise the quest for a regional identity by relating the efforts of integration to the issues of multi-ethnicity,
Kristina Jönsson
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Regional identity and family [PDF]
Sociološki Pregled, 2003 This paper is a continuation of a study on regionalisation and family, within the project named Sociological Aspects of Multiculturality and Regionalisation and their influence on the development of AP Vojvodina and the Republic of Serbia.
Tripković Gordana D.
doaj +3 more sources