Results 81 to 90 of about 3,950,269 (341)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Re-scaling landscape. Re-scaling identity / Keičiant kraštovaizdį, keičiama tapatybė
Mokslas: Lietuvos Ateitis, 2012 To understand the bonds cultural groups living in Estonia have with their cultural landscape and why they identify themselves with a particular territory (region), the general process of presenting the landscape role in their identity needs to be ...
Julia Sulina
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Sprawy Narodowościowe. Seria nowa, 2018 Subjects of the empress. Wider context of regional history education on East Prussia and identity processes in contemporary Kaliningrad oblast Political, economic and social changes brought about by the dissolution of the Soviet Union have had a ...
Miłosz Janusz Zieliński
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A Declining Region: Provincial Renaissance Revisited (Case of Volgograd Region)
Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2014 The paper analyzes findings yielded by the empirical study performed in the framework of an RGNF grant entitled “Image of a region as a communicative strategy for the authorities and mass media”.
Drozdova Yuliya
doaj +1 more source
The ‘Green’ as Element of Regional Identity [PDF]
, 2020 Un’area verde, un parco pubblico dovrebbero sempre rappresentare il genius loci della località in cui si trovano, in molti casi hanno rappresentato l’elemento di cambiamento di un luogo fino a diventarne la caratteristica più importante, se non addirittura il protagonista, il motore di sviluppo di quel sito.
P. Burlando, I. Vagge
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Studia Etnologiczne i Antropologiczne, 2019 The article quotes, as a context for the problematics defined in the title, demographic data indicating systematic decrease of Polish population in Zaolzie. The publication referred to, Wizja 2035.
Mirosława Pindór
doaj +1 more source