Results 141 to 150 of about 12,936,584 (263)

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

open access: yesAdvanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu   +5 more
wiley   +1 more source

Multi-Regional Input-Output Analysis (MRIO): Exploring Trends and Gaining Key Insights Through Bibliometric Analysis

open access: yesManagement Dynamics in the Knowledge Economy
Understanding the interaction of economies with the environment is very important in today's globalized world. Traditional economic models, which focus on single regions, are often inadequate for capturing the complexity of these global interactions. To
Subhasinghe Manchanayake Appuhamilage Vishwanath Sandeepa TENNAKOON
doaj  

How to Estimate Unbiased and Consistent input-output Multipliers on the Basis of use and Make Matrices [PDF]

open access: yes
In the literature, the construction of technical coefficients is linked to flow data (use and make matrices), but stochastics are imposed on the coefficients when multipliers are calculated, by means of the Leontief inverse.
Thijs ten Raa   +1 more
core  

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

open access: yesAdvanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai   +4 more
wiley   +1 more source

Structural changes in the Polish economy - the analysis of input-output [PDF]

open access: yes
This paper analyses the structure of Polish economy using three input-output tables for years 1995, 2000 and 2004. Applying the traditional methods proposed by Rasmussen the sector’s backward and forward linkages are identified.
Olczyk, Magdalena
core  

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

open access: yesAdvanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia   +4 more
wiley   +1 more source

Input-Output in Europe: Trends in Research and Application [PDF]

open access: yes
Indubitably born in the USA, input-output analysis has an important European history, from its very beginnings in the Soviet Union to the postwar huge development of I/O techniques in West and North Europe.
Antille, Gabrielle   +3 more
core  

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