Results 221 to 230 of about 12,936,584 (263)

Disabling COMPASS Promoter Licensing Shifts HDAC‐Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery

open access: yesAdvanced Science, EarlyView.
Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song   +8 more
wiley   +1 more source

Improved Skills for Predicting Sub‐Seasonal to Seasonal Global Sea Surface Temperature

open access: yesAdvanced Science, EarlyView.
Addressing the critical Sub‐seasonal to Seasonal predictability gap, this study presents CAS‐Canglong, a novel deep learning framework. By leveraging 3D Swin‐Transformers to capture long‐range ocean interactions, the model demonstrates superior skill over traditional GCMs.
Longhao Wang   +6 more
wiley   +1 more source

Product‐Reshaped Gas‐Phase Hydrodynamics Govern CO2 Electrolysis in Gas Diffusion Electrodes

open access: yesAdvanced Science, EarlyView.
In gas‐fed CO2${\rm CO}_2$ electrolysers, the gas phase is part of the electrochemical response. As gaseous products form, they change gas composition and flow, which in turn affects CO2${\rm CO}_2$ delivery and CO intermediate availability. This feedback changes the reaction environment needed for multicarbon formation, becoming unavoidable as ...
Abdullah A. Alyahya   +6 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

open access: yesAdvanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun   +12 more
wiley   +1 more source

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