Results 41 to 50 of about 364,820 (296)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Cognitive and Emotional Impact of Environmental Media Texts on Youth: A Neuromarketing Study
RUDN Journal of Studies in Literature and JournalismThe results of a neuromarketing study of the mental states of the media audience are presented. The aim is to identify the basic emotions of young people in the process of consuming media texts on ecology.
Lidia K. Lobodenko +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Preserving traditional medical knowledge through modes of transmission: A post-positivist enquiry
South African Journal of Information Management, 2014 Background: In Nigeria, most rural communities lack access to orthodox medical facilities despite an expansion of orthodox health care facilities and an increase in the number of orthodox health care providers.
Janet Adekannbi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
PACMAS state of media and communication report 2013 [PDF]
, 2013 The PACMAS State of Media and Communication Report 2013 was undertaken through a partnership between RMIT University (Australia), the University of Goroka (Papua New Guinea) and UNITEC (New Zealand).
Jo Tacchi, Heather Horst
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
Social Media As a Tool of Influence on Regional Audience of the Russian Media
Regionalnaya ekonomika. Yug Rossii, 2021 In the context of competition between the traditional media among themselves and with new media, it is important to improve the methods of influence on the regional audience for the achievement of the goals and survival on media markets of federal entities of the Russian Federation.
Svetlana Pyankova +3 more
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source