Results 41 to 50 of about 310,849 (308)

Science and Technology Parks in Two Lagging Regions of Spain: A Comparative Evaluation Using an Innovation Network Approach [PDF]

open access: yes, 2006
Science and Technology Parks (STPs) have been widely used as innovation support and regional development instruments in most European countries. In Objective 1 regions of South Europe STPs projects were developed during the 90s through regional, national
Tsamis, Achilleas
core  

Approaches to Active Tourism in the Urals and in Perm Krai [PDF]

open access: yes, 2016
Located in the south of Ural, Perm Krai, apart from mineral resources and well-developed industry, can boast vast areas that lend themselves to active and qualified tourism, with the quality of an amateur sport.
Korolev, Andriej Y.   +3 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Sustainable Planning of Land Use Changes in farming areas under ecological protection [PDF]

open access: yes, 2010
Land use has been changing in the last decades because of agricultural intensification and land abandonment which implies deterioration in the optimum habitat structure and quality.
Brasa-Ramos, A.   +3 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Sustainable Landscape Development with Regional Parks - Overcoming Problems of Landscape Multifunctionality in Urban Agglomerations [PDF]

open access: yes, 2005
Urban agglomerations all over Europe are growing at the expense of the surrounding landscapes. Given the enormous growth of built-up land for settlement and transport use within recent decades in Western and Southern Europe and, more recently, comparable
Gailing, Ludger
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Increasing role of tourism in Finnish national parks

open access: yesFennia: International Journal of Geography, 2008
While the role of traditional livelihoods has decreased, tourism has become an important tool for regional development in northern peripheral areas, and the economic and political expectations have increased. National parks have become attractive tourist
Riikka Puhakka
doaj  

European agri-environmental policy and local institutions: A case study on French Regional Nature Parks [PDF]

open access: yes, 2010
Translating the European agro-environmental policy at a local scale implies costs of implementation, especially when a local cohesion is required.
Décamps, Mélanie
core  

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