Results 181 to 190 of about 5,277,322 (299)

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Strengthening Rural Prevention Through Collaborative Partnerships, Funding Diversification, and Youth Engagement. [PDF]

J Public Health Manag Pract
Jarvis LM, Casarez MJ.
europepmc   +1 more source

Supercapacitor Safety: Overcharge‐Induced Failure Mechanisms in Electrochemical Double‐Layer Capacitors

Advanced Science, EarlyView.
Time‐resolved synchrotron radiography reveals the internal evolution of electrochemical double‐layer capacitors under abusive overcharge. EDLCs are shown to follow a thermally driven failure pathway involving electrolyte decomposition, gas generation, and structural collapse, distinct from chemically driven thermal runaway effects of Lithium‐ion ...
Thomas Dore, Inez Kesuma, Abdus S. Ali, Jonas Pfaff, Yuxiao Jin, Rosalie Hamill, Mark Buckwell, Hamish Reid, Thomas Finco, Zeyu Sun, Yuanze Li, Sebastian Schopferer, Siegfried Nau, Nils Böttcher, Henning Markötter, Alexander J. E. Rettie, James Robinson, Paul R. Shearing, Alexander Rack, Thomas S. Miller   +19 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

The Prospective SPOTLESS Trial: Setup Accuracy of Tattoo-Less Surface-Guided Breast Radiotherapy Including Regional Nodal Irradiation. [PDF]

J Clin Med
Meixner E, Albert S, Cepni B, Neugebauer D, Lau HH, Thater J, Herfarth K, Mende S, Weykamp F, Ayestaran-Aldaz A, Hoeltgen L, Arians N, Liermann J, Wessel L, Harrabi S, Waldsperger H, Debus J, Klüter S, Batista V.   +18 more
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Data-Driven Healthy China Pathway: Evolution, Framework, and Global Implications of National Digital Health Strategic Planning. [PDF]

J Med Internet Res
Liu J, Liu S.
europepmc   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Rapid Cooling After Device Annealing Suppresses Interface Losses in Cu2ZnSnS4 Solar Cells Enabling High Efficiency and Stability

Advanced Science, EarlyView.
Rapid cooling after device annealing regulates the CdS/CZTS heterojunction and Mo/CZTS back contact, suppressing interfacial recombination and modifying the interfacial MoS2 layer, thereby enabling a 15.9% indoor PCE in pure‐sulfide CZTS solar cells.
Achmad Nasyori, Mati Danilson, Idil Mengü, Maris Pilvet, Jüri Krustok, Reelika Kaupmees, Valdek Mikli, Raavo Josepson, Yuancai Gong, Akhil Alexander, Shreyash S. Hadke, Aurelian Catalin Galca, Paola Vivo, Lydia Helena Wong, Thomas Unold, Maarja Grossberg‐Kuusk, Marit Kauk‐Kuusik   +16 more
wiley   +1 more source

Making Home-Based End-of-Life Care a Realistic Choice: A Narrative Review of Linkages Between Community Care and Specialized Hospice Institutions in South Korea. [PDF]

J Hosp Palliat Care
Kwon SH.
europepmc   +1 more source