Results 31 to 40 of about 264,706 (233)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Resilience Concept in Indonesian Small Town Development and Planning: a Case of Lasem, Central Java

E3S Web of Conferences, 2018
Rapid urbanization in developing countries has brought some unprecedented consequences in economic, social, and most notably environmental aspects. Many cities have to be dealing with the challenges of vulnerability as the risk of disasters increases. In
Setyono Jawoto Sih, Handayani Wiwandari, Rudiarto Iwan, Esariti Landung   +3 more
doaj   +1 more source

تقييم القدرات التنافسية للإقتصاد المحلى للمجتمعات المحلية المصرية ذات الإقتصاد المحلى الحرفى Assessment of the competitiveness of the local economy of the Egyptian local communities with local Economy handicrafts [PDF]

Journal of Urban Research
يتناول البحث قياس القدرات التنافسية التى تمثل إحدى الآليات لتقييم التفاعلات للإقتصاد المحلى للمجتمعات المحلية الوظيفية ،وذلك من خلال تحليل لمجموعة من المؤشرات والمتغيرات التى تساعد فى تقييم قدرة المجتمع المحلى فى المنافسة بالتطبيق على التجربة المصرية.حيث
Fatma Hassan Ahmad, Hend Mohamed Mostafa Al-Abbasy, Gihan Hassan   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Land use and meteorological influences on dengue transmission dynamics in Dhaka city, Bangladesh

Bulletin of the National Research Centre
Background Dengue fever, a viral illness spread mostly by Aedes mosquitoes, continues to pose a substantial public health issue in Dhaka city, Bangladesh.
Sudipta Roy, Abhijit Biswas, Mst. Tanzila Aktar Shawon, Samia Akter, Mohammad Mizanur Rahman   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Spatio-Temporal of NO2 Density Weighting in The Region of Malang, East Java Province, Indonesia [PDF]

E3S Web of Conferences
The paper aimed to present the spatio-temporal of NO2 Density Weighting during the period April 2022 – March 2023 (1 year) with weighting model in The Region of Malang, East Java Province, Indonesia.
Pamungkas Guntur Bagus, Kurniawati Aynunnisaa, Iskandar Cut Marcella   +2 more
doaj   +1 more source

Hubungan keragaman guna lahan dalam urban compactness dengan ketersediaan lahan parkir di Kota Surakarta

Region: Jurnal Pembangunan Wilayah dan Perencanaan Partisipatif, 2022
Perkembangan kota membutuhkan ketersediaan lahan agar mampu memenuhi kegiatan perkotaan. Optimalisasi lahan diperlukan untuk menampung seluruh kegiatan yang terjadi dalam suatu kota. Salah satu caranya dengan penggunaan lahan campuran.
Feira Ariani, Rizon Pamardhi Utomo, Nur Miladan   +2 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source