Results 31 to 40 of about 394,192 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Human-Centered Urban Transformation for the Egyptian urban communities - Sheikh Zayed City Case study [PDF]

JES: Journal of Engineering Sciences
Egypt's new towns have predominantly followed top-down, infrastructure-led development approaches that prioritize physical expansion while often neglecting human-centered outcomes.
Mohammed Farid, Seham Mostafa, Tarek Zaki, Marwa Hamid   +3 more
doaj   +1 more source

Analysis of Pedestrian Travel Demand for Bus Trans Semarang through 3D Method (Density, Diversity, Design)

Jurnal Teknik Sipil dan Perencanaan, 2020
The growing number of private transportation ownership from year to year creates congestion problems, especially in urban areas. Public transportation conditions such as the Rapid Transit Bus (BRT) are an alternative way to use transportation.
Anita Ratnasari Rakhmatulloh, Diah Intan Kusumo Dewi, Dinar Mutiara Kusumo Nugraheni   +2 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Pandemic Responsive Spaces for Local Economic Activities in the Old Town of Semarang

International Journal of Built Environment and Sustainability, 2022
The COVID-19 pandemic has changed all aspects of life and order. It has made the Old Town of Semarang experience a decrease in the number of visitors.
Wakhidah Kurniawati, Rina Kurniati, Sugiono Soetomo, R. Rafii Bisatya Rahmat   +3 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Land use and meteorological influences on dengue transmission dynamics in Dhaka city, Bangladesh

Bulletin of the National Research Centre
Background Dengue fever, a viral illness spread mostly by Aedes mosquitoes, continues to pose a substantial public health issue in Dhaka city, Bangladesh.
Sudipta Roy, Abhijit Biswas, Mst. Tanzila Aktar Shawon, Samia Akter, Mohammad Mizanur Rahman   +4 more
doaj   +1 more source

Resilience Concept in Indonesian Small Town Development and Planning: a Case of Lasem, Central Java

E3S Web of Conferences, 2018
Rapid urbanization in developing countries has brought some unprecedented consequences in economic, social, and most notably environmental aspects. Many cities have to be dealing with the challenges of vulnerability as the risk of disasters increases. In
Setyono Jawoto Sih, Handayani Wiwandari, Rudiarto Iwan, Esariti Landung   +3 more
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source