Results 81 to 90 of about 534,765 (265)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Is Territorial Cohesion Necessary for the Sustainable Development of the European Regions? [PDF]

Romanian Review of Regional Studies, 2011
The Regional policy of the EU is pursuing the harmonious development of the European territory; this is a necessary condition for the creation of an environment that is favourable to the convergence of the Union’s policies.
RADU C. BARNA
doaj  

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

A descriptive summary of the WHO availability assessments of medical abortion medicines in eight African countries

Reproductive Health
Background The use of medical abortion using either a combination of mifepristone and misoprostol, or misoprostol alone has contributed to increased safety and decreased mortality and morbidity.
Amy Grossman, Ndola Prata, Sarah Jones, Laurence Läser, Bela Ganatra, Antonella Lavelanet, Natalie Williams, Chilanga Asmani, Hayfa Elamin, Leopold Ouedraogo, Lucy Sejo Maribe, Dina Vladimirovna Gbenou, Yelmali Clotaire Hien, Moussa Dadjoari, Fousséni Dao, Mariette Claudia Adame Gbanzi, Robert Mulunda Kanke, Franck Biayi Kanumpepa, Dudu Dlamini, Grace Motsoanku Mefane, Sirak Hailu Bantiewalu, Mary Nana Ama Brantuo, Olive Sentumbwe-Mugisa, Richard Mugahi, Olumuyiwa Adesanya Ojo, Adeniyi Kolade Aderoba, Ulrika Rehnström Loi   +26 more
doaj   +1 more source

Regional Innovation Strategies in the Czech Republic [PDF]

Journal of Competitiveness, 2011
Lately, the concept of innovation has become a development mantra in the fierce global competition. Competition is not limited to firms; it is also relevant for territories.
Hájek Oldřich, Grebeníček Pavel, Novosák Jiří   +2 more
doaj  

A network model of Italy shows that intermittent regional strategies can alleviate the COVID-19 epidemic. [PDF]

Nat Commun, 2020
Della Rossa F, Salzano D, Di Meglio A, De Lellis F, Coraggio M, Calabrese C, Guarino A, Cardona-Rivera R, De Lellis P, Liuzza D, Lo Iudice F, Russo G, di Bernardo M.   +12 more
europepmc   +1 more source