Results 231 to 240 of about 42,518,722 (284)
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
Molecular Interlayer for High‐Performance and Stable 2D Tin Halide Perovskite Transistor
Advanced Science, EarlyView.Molecular interlayers are designed for p‐channel 2D Sn halide thin‐film transistors, yielding exceptional performance metrics, a significant reduction in hysteresis, and enhanced ambient stability. The effectiveness of new molecular interlayers (TPOF1, TPOF2, and 2F‐TOPF2) is confirmed by surface treatment, demonstrating remarkable carrier mobility ...
Bum Ho Jeong +6 more
wiley +1 more source
Advanced Science, EarlyView.This work explores the process of morning awakening of the human brain using polysomnography paired with simultaneous stereo‐electroencephalography, a method that provides high spatial and temporal resolution for examining brain activity. Awakening is characterized by an increase in high‐frequency spectral power and connectivity.
Tamir Avigdor +5 more
wiley +1 more source
Advanced Science, EarlyView.Migrasomes are newly discovered organelles in migrating cells. This study finds that osteosarcoma cell‐derived migrasomes promote the tumor‐promoting phenotype of macrophages and further aggravate osteosarcoma malignant progression via milk fat globule‐EGF factor 8.
Wanshun Liu +10 more
wiley +1 more source
Advanced Science, EarlyView.This study provides support for the immunity debt hypothesis, revealing a 131.72% increase in influenza rates during winter and a 161.23% rise in summer, 1 year following the global easing of COVID‐19 restrictions. This study offers empirical evidence of immunity debt on a global level, highlighting the importance of incorporating this concept into the
Li Chen +6 more
wiley +1 more source
Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function
Advanced Science, EarlyView.CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy +6 more
wiley +1 more source
Advanced Science, EarlyView.Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae +9 more
wiley +1 more source