Results 201 to 210 of about 1,403 (285)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

A dataset of floating debris accumulation at bridges after July 2021 flood in Germany and Belgium. [PDF]

Sci Data
Erpicum S, Poppema D, Burghardt L, Benet L, Wüthrich D, Klopries EM, Dewals B.   +6 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, Volume 36, Issue 4, July 2026.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors. [PDF]

Leukemia
Jelinek T, Zihala D, Sevcikova T, Anilkumar Sithara A, Kapustova V, Sahinbegovic H, Venglar O, Muronova L, Broskevicova L, Nenarokov S, Bilek D, Popkova T, Plonkova H, Vrana J, Zidlik V, Hurnik P, Havel M, Hrdinka M, Chyra Z, Stracquadanio G, Simicek M, Hajek R.   +21 more
europepmc   +1 more source

Applications of ChatGPT in the Health Sector: A Systematic Literature Review

Expert Systems, Volume 43, Issue 7, July 2026.
ABSTRACT The integration of large language models, particularly ChatGPT, into healthcare has attracted increasing attention due to their potential to support medical education, clinical decision‐making, administrative workflows, patient communication and clinical documentation.
Alejandro Martínez‐Burgos, Elena Enamorado‐Díaz, Javier Jesús Gutiérrez‐Rodríguez, Julián A. García‐García   +3 more
wiley   +1 more source

Phosphoric acid salts of amino acids as a source of oligopeptides on the early Earth. [PDF]

Commun Chem
Šponer JE, Coulon R, Otyepka M, Šponer J, Siegle AF, Trapp O, Ślepokura K, Zdráhal Z, Šedo O.   +8 more
europepmc   +1 more source

A stage‐dependent seed defense response to explain efficient seed transmission of Xanthomonas citri pv. fuscans to common bean

Plant, Cell &Environment, Volume 49, Issue 7, Page 3500-3517, July 2026.
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse, Łukasz Paweł Tarkowski, Martial Briand, David Lalanne, Nicolas W. G. Chen, Matthieu Barret, Jerome Verdier   +6 more
wiley   +1 more source

Ancestral genetic components are consistently associated with the complex trait landscape in European biobanks. [PDF]

Eur J Hum Genet
Pankratov V, Mezzavilla M, Aneli S, Kuznetsov IA, Fusco D, Wilson JF, Metspalu M, Provero P, Pagani L, Marnetto D.   +9 more
europepmc   +1 more source

Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais, Rajendra Rohokale, Sevin Mamputu, Ion Lupu, Zhongwu Guo, Sébastien Balieu   +5 more
wiley   +1 more source

De novo assembly of complete circular mitochondrial genomes from 2,695 fungal species. [PDF]

Sci Data
Sarhan MS, Abdalrahem A, Maixner F, Fuchsberger C.   +3 more
europepmc   +1 more source