Results 211 to 220 of about 10,201,960 (347)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Exploration of Energy Transition Paths in Resource-Based Regions Based on the Multi-Energy Coupled New Energy System [PDF]

Yang Hongmei, Zhai Zhiwei
openalex   +1 more source

Molecular polymorphisms that underlie trait variation in crops: Lessons learned from soybean. [PDF]

Plant Genome
Espina MJC, Lorenz AJ, Stupar RM.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Current state, issues and prospects of the halal industry development in Russian regions (using the example of the Republic of Bashkortostan)

V. Ya. Akhmetov, F. V. Matinova
openalex   +2 more sources

A Global, Regional, and National Survey on Burden and Quality of Care Index of Alzheimer's Disease and Other Dementias in Adults Aged 55 and Above: The Global Burden of Disease Study 1990-2021.

Neuroepidemiology
Chen YH, Li S, Yu C, Liao Y, Wang LN, Yang B.   +5 more
europepmc   +1 more source

Regulating Negative Autobiographical Memories: An fMRI Investigation of Reappraisal and Distraction in Middle-aged and Older Adults. [PDF]

J Cogn Neurosci
Graner JL, Faul L, Diehl JM, Madden DJ, Smoski MJ, LaBar KS.   +5 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Generational renewal in agriculture: What’s the problem represented to be? Deconstructing Policy Representations in Rural Development Programmes across Italian regions [PDF]

Federica Consentino, Ruth McAreavey, Iuri Peri   +2 more
openalex   +1 more source

Detecting anthropogenically induced changes in extreme and seasonal evapotranspiration observations. [PDF]

Nat Commun
Egli M, Sippel S, Knutti R, Humphrey V.
europepmc   +1 more source