Results 221 to 230 of about 10,201,960 (347)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Ground-Motion Prediction Equations Based on Data from the Himalayan and Zagros Regions

, 2009
M. L. Sharma, John Douglas, H. Bungum, Jainish Kotadia   +3 more
openalex   +2 more sources

Spatial distributions, driving factors, and future changes of soil organic carbon in China: arid regions vs. humid regions. [PDF]

Sci Rep
Yang B, Zhang S, Wang X.
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dark and camouflaged genomic regions remain challenging in CHM13. [PDF]

Sci Rep
Wadsworth ME, Page ML, Heberle BA, Miller JB, Steely CJ, Ebbert MTW.   +5 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Ethnobotanical survey of antimalarial and mosquito-repellent plants in the Centre and Hauts-Bassins Regions of Burkina Faso

Mariam Youba, Domonbabélé François de Sales Hien, Saamou Isaac Boni, Kouliga Benjamin Koama, Samuel Paré, Nâg-Tiero Roland Meda, Rakiswendé Serge Yerbanga, Thierry Léfèvre, Roch K. Dabiré, Olivier Gnankiné   +9 more
openalex   +2 more sources

Dynamic responses of gross primary productivity to compound hot extremes and drought across different geographical regions of China. [PDF]

Front Plant Sci
Qin Y, Jiang Q, Zhao Y, Wang Z, Tao M, Li B.   +5 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Using multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with cognitive performance. [PDF]

Transl Psychiatry
Qiu S, Zhang Z, Liang H, Guo J, You H, Hu Y, Liu J, Wang Y.   +7 more
europepmc   +1 more source