Results 81 to 90 of about 3,882,526 (268)
4 Right care at the right time: a care model redesign quality improvement project
BMJ Open Quality, 2021 William Bekker +9 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Specific Features of Paradiplomacy in Russia
Управленческое консультирование, 2018 The article is devoted to the development of paradiplomacy in Western Europe and North America. The author reveals the concept of paradiplomacy and compares it with the trans-border regional cooperation (TbRC) in Russia.
Natalya Vyacheslavovna Yakovleva +2 more
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Управленческое консультирование, 2018 This article examines the creation and functioning of the territories of priority socio-economic development (TOR) in the regions of Russia. It is proposed to extend the legal regime of TOR not only on the territory of the Far East and Eastern Siberia ...
Elena Sergeevna Charkina
doaj
Regions, regionalisms and identities:towards a regional mess
, 2017 Abstract This chapter seeks to interrogate the transformation of regions, in order to tease out the sometimes paradoxical relationship between various approaches to conceptualising space. It aims to connect discussions on different kinds of regions and regionalisms, considering both deinstitutionalisation and institutionalisation processes. The chapter
openaire +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
, 1997 In many geographical applications there is a need to model spatial phenomena not simply by sharp objects but rather through indeterminate or vague concepts. To support such applications we present a model of vague regions which covers and extends previous approaches. The formal framework is based on a general exact model of spatial data types.
Erwig, Martin, Schneider, Markus
openaire +2 more sources