Results 91 to 100 of about 1,669,450 (308)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Remote Sensing, 2017 Cold regions affect global, regional and local climate; oftentimes they are relevant for water supply, host valuable ecosystems, and support human livelihood. They are thus eminently important for human society.
Zhongyang Hu +3 more
doaj +1 more source
Spatial inequalities in life expectancy within postindustrial regions of Europe: a cross-sectional observational study [PDF]
, 2014 Objectives To compare spatial inequalities in life expectancy (LE) in West Central Scotland (WCS) with nine other postindustrial European regions.<p></p> Design A cross-sectional observational study.<p></p> Setting WCS and ...
Hanlon, Philip +7 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
PLoS ONE, 2019 Many studies have shown that childhood circumstances can have long term consequences that persist until old age. To better understand the transmission of early life circumstances, this paper analyses the effects of health and financial situation during ...
Claudia Börnhorst +2 more
doaj +1 more source
Development and Religious Polarization: The Emergence of Reform and Ultra-Orthodox Judaism [PDF]
Jewish emancipation in nineteenth century Europe produced drastically different responses. In Germany, a liberal variant known as Reform developed, while ultra-Orthodox Judaism emerged in eastern Europe. We develop a model of religious organization which
Jean-Paul Carvalho, Mark Koyama
core
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Survey on brachytherapy training among radiation oncology residents in the German-speaking regions of Europe. [PDF]
Strahlenther Onkol, 2023 Knoth J +10 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source