Results 101 to 110 of about 1,669,450 (308)

Non-linear loss of suitable wine regions over Europe in response to increasing global warming. [PDF]

open access: yesGlob Chang Biol, 2023
Sgubin G   +10 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Regional quality of living in Europe

open access: yesREGION, 2015
This article sets out the conceptual framework and results of Regional Quality of Living indicators that were developed in order to benchmark European NUTS2 regions. Nine non-business-related indicators are constructed to support the goal of policy makers to improve the attractiveness of regions and cities for people or companies to settle in, and by ...
Lagas, Piet   +3 more
openaire   +6 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Regional Geography of Europe [PDF]

open access: yesThe Geographical Journal, 1922
L. W. L., N. E. MacMunn, G. Coster
openaire   +1 more source

Location Choices of Multinational Firms in Europe: the Role of National Bourdaries and EU Policy [PDF]

open access: yes
We examine the determinants of multinational firms’ location choices in Europe by estimating a nested logit model on a data-set of 5,761 foreign subsidiaries established in 55 regions in 8 EU countries over the period 1991-1999.
Davide Castellani, Roberto Basile
core  

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

Regional development traps in Europe: a study of occupational trajectories of regions

open access: yesCambridge Journal of Regions, Economy and Society
Abstract This paper presents an evolutionary perspective on regional development traps that centres around the structural inability of regions to develop new and complex occupations. Using the European Labour Force Survey, we follow occupational trajectories of 237 European regions and provide evidence on which regions are trapped ...
Milene Simone Tessarin   +3 more
openaire   +3 more sources

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