Results 121 to 130 of about 1,669,450 (308)

Regional specialization and trade patterns in Europe. [PDF]

open access: yes
In the present paper we will study the effects of the construction of an internal market in Europe in 1992. The question to be answered is whether some regions in Europe have improved their positions in the internal EU trade from a better exploitation of
Frias, Isidro   +2 more
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Regional differences in productivity growth in The Netherlands: an industry-level growth accounting [PDF]

open access: yes
It is well known that the productivity growth in Europe is slowing down, against an increasing growth rate in the US. The Netherlands is one of countries in Europe with the lowest growth rates of productivity.
Broersma, Lourens, Dijk, Jouke van
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Mapping the European regional educational distribution: Educational attainment and inequality [PDF]

open access: yes
The geography of education, especially at sub-national level, is a huge black box. Basically nothing is known about the distribution of educational attainment and inequality across regions in Europe.
Andrés Rodríguez-Pose   +1 more
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

The second transition: Eastern Europe in perspective [PDF]

open access: yes
This paper studies the global trade and financial market integration of the countries in Eastern Europe. The countries of Eastern Europe achieved two remarkable transitions in the short period of the last two decades: from plan to market and, then, in ...
Ashoka Mody   +2 more
core  

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