Results 81 to 90 of about 1,669,450 (308)

Instead of simply paying for losses, Europe should institutecost-effective adaptation measures to meet the challengesposed by climate change. [PDF]

, 2012
Climate change is no longer an abstract concept, but one that is costing Europe and the world in both human and economic terms. Writing that climate change could cost the world trillions every year within a few decades, Annika Ahtonen argues for more ...
Ahtonen, Annika
core  

The Importance Of Human Capital For The Economic Development Of EU Regions [PDF]

, 2016
According to the research results, the highest levels of human capital are typical of the most affluent regions in Western Europe, while its lowest levels are found in the poorest countries that became EU members only recently and in countries in ...
Dańska-Borsiak, Barbara, Laskowska, Iwona   +1 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Population Transformations in Traditional Economic Regions of Central Europe. Structural Approach

Bulletin of Geography. Socio-Economic Series, 2008
The subject of the Author's interest are traditional social-economic regions of Central Europe, i.e. the Katowice and Rybnik conurbations in Poland, and the Ostrava-Karvina agglomeration in the Czech Republic.
Jerzy Runge
doaj   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Insights into globalization: comparison of patient characteristics and disease progression among geographic regions in a multinational Alzheimer’s disease clinical program

Alzheimer’s Research & Therapy, 2018
Background Globalization of clinical trials has important consequences for trial planning and interpretation. This study investigated heterogeneity in patient characteristics and outcomes among world regions in the global idalopirdine Phase 3 clinical ...
Jeffrey L. Cummings, Alireza Atri, Clive Ballard, Neli Boneva, Lutz Frölich, José Luis Molinuevo, Lars Lau Raket, Pierre N. Tariot   +7 more
doaj   +1 more source

Innovation systems in regions of Europe: A comparative perspective [PDF]

The understanding of the innovation process has changed considerably in the past years. Models have shifted from linear and firm based conceptions towards interdependent and systemic approaches.
Franz Todtling
core  

Conference Report The 16th Asia Europe Economic Forum. EU-Asia trade and investment connectivity [PDF]

, 2020
Global economic trends over the last decades have steadily increased the links between Asia and Europe. For both regions, a growing economic interdependency represents an opportunity to build strong, fair and sustainable relations.
Coka, Daniela Arregui, Jungbluth, Cora
core