Results 41 to 50 of about 339,354 (256)

Improved genetic prediction of complex traits from individual-level data or summary statistics

Nature Communications, 2021
Existing genetic prediction tools typically assume that genetic variants contribute equally towards the phenotype. The authors develop eight prediction tools that allow the user to specify the heritability model, and show that these tools enable ...
Qianqian Zhang, Florian Privé, Bjarni Vilhjálmsson, Doug Speed   +3 more
doaj   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

Nitrate in drinking water and risk of birth defects: Findings from a cohort study of over one million births in Denmark

The Lancet Regional Health. Europe, 2022
Summary: Background: A few studies have reported an increased risk of birth defects (BD) with maternal exposure to nitrate in drinking water. We examined this association in a large cohort study with well-characterized exposure.
Leslie Thomas Stayner, Anja Søndergaard Jensen, Jörg Schullehner, Vanessa R. Coffman, Betina B. Trabjerg, Jørn Olsen, Birgitte Hansen, Marie Pedersen, Carsten B. Pedersen, Torben Sigsgaard   +9 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Long-term exposure to air pollution and mortality in the Danish population a nationwide study

EClinicalMedicine, 2020
Background: Studies have shown higher mortality in association with exposure to air pollution. We investigated this association with focus on differences between socioeconomic groups.
Ole Raaschou-Nielsen, Erla Thorsteinson, Sussie Antonsen, Gitte J Holst, Torben Sigsgaard, Camilla Geels, Lise M Frohn, Jesper H Christensen, Jørgen Brandt, Carsten B Pedersen, Ulla A. Hvidtfeldt   +10 more
doaj   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia

Nature Communications, 2018
Schizophrenia (SCZ) risk is influenced by genetic and environmental factors. Here, the authors develop a statistical method for analyzing gene-by-environment effects in SCZ risk across Denmark with fine spatial resolution.
Chun Chieh Fan, John J. McGrath, Vivek Appadurai, Alfonso Buil, Michael J. Gandal, Andrew J. Schork, Preben Bo Mortensen, Esben Agerbo, Sandy A. Geschwind, Daniel Geschwind, Thomas Werge, Wesley K. Thompson, Carsten Bøcker Pedersen   +12 more
doaj   +1 more source

Parental exposures to occupational asthmagens and risk of autism spectrum disorder in a Danish population-based case-control study

Environmental Health, 2017
Background Environmental exposures and immune conditions during pregnancy could influence development of autism spectrum disorder (ASD) in offspring. However, few studies have examined immune-triggering exposures in relation to ASD.
Alison B. Singer, Igor Burstyn, Malene Thygesen, Preben Bo Mortensen, M. Daniele Fallin, Diana E. Schendel   +5 more
doaj   +1 more source

Income disparities between adult childhood cancer survivors and their peers—A register‐based cohort study from the SALiCCS research programme

Cancer Medicine, 2023
AbstractBackgroundChildhood cancer survivors face various adverse consequences. This Nordic register‐based cohort study aimed to assess whether survivors of childhood cancer are more likely to have low income than their peers.MethodsWe identified 17,392 childhood cancer survivors diagnosed at ages 0 to 19 between 1971 and 2009 with 83,221 age‐, sex ...
Anniina Kyrönlahti, Friederike Erdmann, Maria Feychting, Line Elmerdahl Frederiksen, Elli Hirvonen, Liisa Maria Korhonen, Anja Krøyer, Luzius Mader, Nea Malila, Hanna Mogensen, Camilla Pedersen, Mats Talbäck, Mervi Taskinen, Jeanette Falck Winther, Laura Madanat‐Harjuoja, Janne Pitkäniemi   +15 more
openaire   +6 more sources

Improved Early Referral in Long‐Term Survivor Care With Institutional Standardized Practice Among Childhood Leukemia Survivors#

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In 2018, the Texas Children's Cancer and Hematology Center Leukemia Program implemented a practice standard to support the transition from treatment to survivorship that includes shared, alternating care between leukemia and survivorship clinicians and a reminder to refer survivors to the long‐term survivor clinic (LTSC) 2 years after ...
Ji Yun Tark, Kayla L. Foster, Omar Shakeel, Mary C. Shapiro, Shawki L. Qasim, ZoAnn Dreyer, Eric S. Schafer, Ashley M. Butler, Austin L. Brown, Maria Monica Gramatges   +9 more
wiley   +1 more source