Results 91 to 100 of about 7,640,907 (324)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Kernel matrix regression

, 2007
We address the problem of filling missing entries in a kernel Gram matrix, given a related full Gram matrix. We attack this problem from the viewpoint of regression, assuming that the two kernel matrices can be considered as explanatory variables and ...
Vert, Jean-Philippe, Yamanishi, Yoshihiro   +1 more
core   +1 more source

Elementary Landscape Decomposition of the Test Suite Minimization Problem [PDF]

, 2015
Chicano, F., Ferrer J., & Alba E. (2011). Elementary Landscape Decomposition of the Test Suite Minimization Problem. In Proceedings of Search Based Software Engineering, Szeged, Hungary, September 10-12, 2011. pp.
Alba-Torres, Enrique, Chicano, Francisco, Ferrer, Javier   +2 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Modeling and Prediction of Occupancy in Buildings Based on Sensor Data Using Deep Learning Methods

IEEE Access
Accurate modelling and prediction of indoor occupancy can lead to efficient optimization and control of building energy consumption. This research uses indirect ambient sensor measurements and heterogeneous data types, together with state of the art ...
Georgiana Cretu, Iulia Stamatescu, Grigore Stamatescu   +2 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Modeling new-firm growth and survival with panel data using event magnitude regression

, 2022
Frédéric Delmar, Jonas Wallin, Ahmed Maged Nofal   +2 more
openalex   +2 more sources

GAN with an Auxiliary Regressor for the Fast Simulation of the Electromagnetic Calorimeter Response [PDF]

, 2023
A. Rogachev, F. Ratnikov
openalex   +1 more source

Regression-aware decompositions

, 2018
Linear least-squares regression with a "design" matrix A approximates a given matrix B via minimization of the spectral- or Frobenius-norm discrepancy ||AX-B|| over every conformingly sized matrix X.
Tygert, Mark
core