Results 101 to 110 of about 7,640,907 (324)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation [PDF]

, 2015
Alexander P. Fields, Edwin H. Rodriguez, Marko Jovanović, Noam Stern‐Ginossar, Brian J. Haas, Philipp Mertins, Raktima Raychowdhury, Nir Hacohen, Steven A. Carr, Nicholas T. Ingolia, Aviv Regev, Jonathan S. Weissman   +11 more
openalex   +1 more source

Logistic Regression Model Using Scheimpflug-Placido Cornea Topographer Parameters to Diagnose Keratoconus [PDF]

, 2021
Emre Altınkurt, Ozkan Avci, Orkun Müftüoğlu, Adem Uğurlu, Zafer Cebeci, Kemal Turgay Özbilen   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

MODELING HYPERTENSION DISEASE RISK IN INDONESIA USING MULTIVARIATE ADAPTIVE REGRESSION SPLINE AND BINARY LOGISTIC REGRESSION APPROACHES

Barekeng
In the pursuit of the Sustainable Development Goals (SDGs), health-related challenges, especially hypertension, remain a significant global issue. The third goal of the SDGs aims to improve the quality of life and well-being of all individuals, but ...
Nur Chamidah, Ardana Tegar Hendrawan, Figo Surya Ardiyanto, Martha Sayyida Hammami, Nurul Izzah, Salsabila Niken Hariadi   +5 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

An Explainable Framework Integrating Local Biplots and Gaussian Processes for Unemployment Rate Prediction in Colombia

Computation
Addressing unemployment is essential for formulating effective public policies. In particular, socioeconomic and monetary variables serve as essential indicators for anticipating labor market trends, given their strong influence on employment dynamics ...
Diego Armando Pérez-Rosero, Diego Alejandro Manrique-Cabezas, Jennifer Carolina Triana-Martinez, Andrés Marino Álvarez-Meza, German Castellanos-Dominguez   +4 more
doaj   +1 more source

Spike-and-Slab Priors for Function Selection in Structured Additive Regression Models [PDF]

, 2012
Fabian Scheipl, Ludwig Fahrmeir, Thomas Kneib   +2 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

HOW TAX POLICIES SHAPE INVESTMENT DECISIONS IN EMERGING ECONOMIES [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
This research examines the impact of fiscal policy on private investment in emerging economies, focusing on the effects of indirect taxes, public expenditures, and budget deficits.
DOBROTĂ GABRIELA , DAN NICOLETA, POPA DANIELA   +2 more
doaj