Results 131 to 140 of about 7,640,907 (324)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Introducing Thermodynamics-Informed Symbolic Regression -- A Tool for Thermodynamic Equations of State Development [PDF]
, 2023 Viktor Martinek +3 more
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
AIMS BiophysicsArtificial neural networks (ANNs) have transformed machine learning and computational intelligence by providing unprecedented powers in modeling complicated data and addressing a wide range of challenges.
Muhammad Asif Zahoor Raja +3 more
doaj +1 more source
The Geographically Weighted Regression Framework
, 2020 Mehak Sachdeva, Stewart Fotheringham
openalex +1 more source
The Annals of Statistics, 1986 Let \(S^ p\) be the unit radius sphere in p-dimensional Euclidean space. Consider the following problem in ''spherical regression''. Let \(u_ 1,...,u_ r\) be fixed points in \(S^ p\) and let \(\nu_ 1,...,\nu_ r\) be random points on \(S^ p\), independently distributed such that the density of \(\nu_ i\) is of the form \(g(\nu_ i'Au_ i)\) with respect ...
openaire +2 more sources
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Analysis of Seasonal Patterns in the Performance of Fuel Markets in the Visegrad Group
Comparative Economic ResearchThe objective of the paper is to examine seasonal patterns in the performance of fuel markets in the Visegrad Group (V4) countries (i.e., the Czech Republic, Hungary, Poland, and Slovakia). Unlike numerous papers that investigate global oil markets, this
Monika Krawiec, Anna Górska
doaj +1 more source
Credit card churn forecasting by logistic regression and decision tree
, 2011 Guangli Nie +4 more
openalex +1 more source
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source