Results 71 to 80 of about 6,113,629 (258)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Using Quantile Regression for Duration Analysis [PDF]
Quantile regression methods are emerging as a popular technique in econometrics and biometrics for exploring the distribution of duration data. This paper discusses quantile regression for duration analysis allowing for a flexible specification of the ...
Fitzenberger, Bernd, Wilke, Ralf A.
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Functional linear regression analysis for longitudinal data
, 2006 We propose nonparametric methods for functional linear regression which are designed for sparse longitudinal data, where both the predictor and response are functions of a covariate such as time.
Müller, Hans-Georg +2 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Regression modeling of different proteins using linear and multiple analysis [PDF]
Network Biology, 2017 There are different types of regression analysis. Out of which simple regression and multiple regressions was considered in this paper. For calculation purpose we have used PLS analysis which calculates squared r values.
Shruti Jain
doaj
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
MODELING ROMANIANS’ LEVEL OF LIFE SATISFACTION [PDF]
Revista Română de Statistică, 2012 As a multi-dimensional indicator that captures the quality of life and wellbeing, the level of life satisfaction is very important for designing future policy The present analysis will focus on the study of life satisfaction based on the Romanian ...
Roxana-Otilia-Sonia HRIŢCU
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Measuring Determinants of Investor Confidence through Time: A Regression Analysis [PDF]
, 2013 This project explores variables that may affect investor confidence in the stock market. Understanding what drives investor confidence in markets can be useful for both institutions and individuals when considering how to react to and cope with the ...
Yox, Paul
core +2 more sources