Results 71 to 80 of about 2,496,534 (248)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Weather-Based Nonlinear Regressions for Digital TV Received Signal Strength Prediction

Elektronika ir Elektrotechnika
In this research, the impact of various weather conditions on digital television signals is investigated. Machine learning and nonlinear regression models were used to estimate the strength of the received signal.
Ivana Stefanovic, Marija Malnar, Snezana Mladenovic, Milutin Nesic   +3 more
doaj   +1 more source

Antiretroviral effects on HIV‐1 RNA, CD4 cell count and progression to AIDS or death: a meta‐regression analysis [PDF]

, 2008
E. Mills, Steven Kelly, Michelle Bradley, Patrick Mollon, Cyrus Cooper, Jean B. Nachega   +5 more
openalex   +1 more source

COVID-19 in India: Lockdown analysis and future predictions using Regression models [PDF]

, 2021
K. Prathyusha, K Helini, Ch. V. Raghavendran, NSL Kumar Kurumeti   +3 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Evaluation of a Pre-Cut Sugarcane Planter for Seeding Performance

Agriculture
To investigate the relationship between the seeding performance of a novel pre-cut sugarcane planter designed by South China Agricultural University and operational settings, field seeding tests was conducted with the following protocol: First, the John ...
Zhikang Peng, Fengying Xu, Pan Xie, Jinpeng Chen, Tao Wu, Zhen Chen   +5 more
doaj   +1 more source

Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study [PDF]

, 2022
Beh Chong You, Ee Meng Cheng, Nashrul Fazli Mohd Nasir, M.S. Abdul Majid, Shing Fhan Khor, M.J.M. Ridzuan, Emma Ziezie Mohd Tarmizi, Kyung‐Sub Lee   +7 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Heavy Fuel Oil Quality Dependence on Blend Composition, Hydrocracker Conversion, and Petroleum Basket

Fuels
The production of very-low-sulfur residual fuel oil is a great challenge for modern petroleum refining because of the instability issues caused by blending incompatible relatively high-sulfur residual oils and ultra-low-sulfur light distillates.
Sotir Sotirov, Evdokia Sotirova, Rosen Dinkov, Dicho Stratiev, Ivelina Shiskova, Iliyan Kolev, Georgi Argirov, Georgi Georgiev, Vesselina Bureva, Krassimir Atanassov, Radoslava Nikolova, Anife Veli, Svetoslav Nenov, Denis Dichev Stratiev, Svetlin Vasilev   +14 more
doaj   +1 more source