Results 71 to 80 of about 26,999,079 (309)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Regression without regrets –initial data analysis is a prerequisite for multivariable regression

BMC Medical Research Methodology
Statistical regression models are used for predicting outcomes based on the values of some predictor variables or for describing the association of an outcome with predictors.
Georg Heinze, Mark Baillie, Lara Lusa, Willi Sauerbrei, Carsten Oliver Schmidt, Frank E. Harrell, Marianne Huebner, on behalf of TG2 and TG3 of the STRATOS initiative   +7 more
doaj   +1 more source

Recipe optimization using regression analysis method

Новые технологии
Introduction. Mathematical modeling in food technology plays a key role in solving many theoretical and practical problems. At the stage of creating new recipes, it becomes one of the effective methods that allows reducing the time and costs of ...
V. A. Bukhovets, O. V. Kartavenko, P. O. Tyurin, G. V. Styrev, D. A. Tverdokhlebova   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Image metadata estimation using independent component analysis and regression [PDF]

, 2006
In this paper, we describe an approach to camera metadata estimation using regression based on Independent Component Analysis (ICA). Semantic scene classification of images using camera metadata related to capture conditions has had some success in the ...
O'Connor, Noel E., Le Borgne, Hervé, Blighe, Michael   +2 more
core   +2 more sources

Illusions in regression analysis

International Journal of Forecasting, 2011
Soyer and Hogarth’s article, 'The Illusion of Predictability,' shows that diagnostic statistics that are commonly provided with regression analysis lead to confusion, reduced accuracy, and overconfidence. Even highly competent researchers are subject to these problems.
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Local linear regression for functional predictor and scalar response [PDF]

, 2007
The aim of this work is to introduce a new nonparametric regression technique in the context of functional covariate and scalar response. We propose a local linear regression estimator and study its asymptotic behaviour.
Baíllo, Amparo, Grané Chávez, Aurea
core   +1 more source

Robust continuum regression. [PDF]

Several applications of continuum regression to non-contaminated data have shown that a significant improvement in predictive power can be obtained compared to the three standard techniques which it encompasses (Ordinary least Squares, Principal ...
Croux, Christophe, Filzmoser, P, Serneels, S, Van Espen, P   +3 more
core   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source