Results 161 to 170 of about 758 (213)

Heterozygous Med13l mice recapitulate a developmental growth delay and craniofacial anomalies seen in MED13L syndrome

Developmental Dynamics, EarlyView.
Abstract Background Gene transcription is crucial for embryo and postnatal development and is regulated by the Mediator complex. Mediator is comprised of four submodules, including the kinase submodule (CKM). The CKM consists of MED13, MED12, CDK8, and CCNC.
Anna K. Leinheiser, Timothy T. Nguyen, Kayla M. Henry, Mariela Rosales, Eric Van Otterloo, Chad E. Grueter   +5 more
wiley   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

A Review of Grain Boundaries: Formation Mechanism, Synthesis Strategy, and Application in Electrocatalysis

EcoEnergy, EarlyView.
An overview of grain boundary engineering in the field of electrocatalysis. ABSTRACT Key electrocatalytic reactions such as HER, OER, ORR, CO2RR, and NRR offer promising routes for storing renewable energy as chemical fuels. However, their widespread application is constrained due to the lack of highly active and stable catalysts. Grain boundaries (GBs)
Jingyu Gao, Fengming Zhou, Xinying Li, Ying Deng, Zexing Wu, Siyuan Feng, Yujing Zhu, Dan Zhang, Zhenyu Xiao   +8 more
wiley   +1 more source

Citizen science deepens the ecological and climatic dimensions of mosquito surveillance

Ecography, EarlyView.
As mosquito‐borne diseases continue to expand worldwide, integrating citizen science into vector surveillance presents untapped potential. This study compares ecological models of Aedes albopictus, an invasive mosquito and global vector of dengue and other arboviruses, in Spain (2020–2022), using two contrasting data sources: traditional traps and ...
Catuxa Cerecedo‐Iglesias, John R. B. Palmer, Frederic Bartumeus   +2 more
wiley   +1 more source

Species traits mediate the abundant‐center patterns in ground‐dwelling mammal and bird species in China

Ecography, EarlyView.
The abundance center hypothesis (ACH) posits that species abundance peaks at distribution centers; however, empirical support remains inconsistent. This study tested the generality of the ACH and investigated species traits as mediators of abundance–distance relationships.
Ludan Zhang, Baoming Zhang, Minghui Zhou, Haoting Duan, Zhipeng Xie, Xinglin Huo, Jiehua Yu, Jiekun He   +7 more
wiley   +1 more source

Revealing Structure–Performance Relations in Core‐Shell Catalyst‐Based PEM Water Electrolyzer Anodes with Low Iridium Loading

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Table of Contents The TiO2@IrO2 core–shell architecture ensures high electronic conductivity even at a low iridium content of 10 wt%. The resulting catalyst layer shows significantly higher iridium utilization than a commercial reference, leading to improved PEMWE single‐cell performance at low iridium loading.
Selina Finger, Darius Hoffmeister, Tien‐Ching Ma, Lena Fiedler, A. Lucía Morales, Andreas Körner, Nico Roubicek, Leopold Lahn, Johannes Böhmer, Thomas Przybilla, Erdmann Spiecker, Olga Kasian, Anna T. S. Freiberg, Karl J. J. Mayrhofer, Simon Thiele, Chuyen van Pham, Andreas Hutzler   +16 more
wiley   +1 more source

Epilepsy in emerging adulthood: Clinical, psychosocial, and surgical challenges

Epilepsia, EarlyView.
Abstract Objective Emerging adulthood (EAs; ages 19–29 years) is a unique developmental stage marked by major psychological, social, and occupational transitions. We sought to characterize the clinical, psychosocial, and surgical features of epilepsy in emerging adulthood, considering both current age and age at epilepsy onset.
Graham A. McLeod, Colin B. Josephson, Samuel Wiebe, The Calgary Comprehensive Epilepsy Program Collaborators, Felippe Borlot, Guillermo Delgado‐García, Paolo Federico, Nathalie Jette, Karl Martin Klein, William Murphy, Neelan Pillay, Andrea Salmon, Shaily Singh, The Epilepsy Surgery Satisfaction Questionnaire Study Group, Mark J. Atkinson, Walter J. Hader, Mark R. Keezer, Oluwaseyi A. Lawal, Sophia Macrodimitris, Kristina Malmgren, Dang K. Nguyen, Scott B. Patten, Tolulope T. Sajobi, Ruby Sharma, Yves Starreveld, José Tellez‐Zenteno, Sandra Wahby   +26 more
wiley   +1 more source

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Regression Discontinuity Design

JAMA, 2020
Regression discontinuity design (RDD) is a causal inference technique that can be used with observational data. Social scientists are often faced with challenges when using observational data in contexts where an experimental design is infeasible. In such contexts, under fewer assumptions relative to other causal inference techniques, an RDD may be ...
Matthew L, Maciejewski, Anirban, Basu
openaire   +3 more sources

The Experiential View of Regressive Discontinuance

2022
Social media has become an essential forum for young adults to engage with each other by exchanging informative, engaging, and entertaining content. Some mobile social media applications are consistently popular among individuals, while some get abandoned after the initial usage.
Mohina Gandhi, Arpan Kumar Kar, P. Vigneswara Ilavarasan   +2 more
openaire   +3 more sources

Nonparametric estimation of a discontinuity in regression

Statistica Neerlandica, 2002
We propose and study a new method to nonparametrically estimate a discontinuity of a regression function. The optimal rate of convergence n−1 is obtained under minimal assumptions. No smoothing is required.
Dempfle, Astrid, Stute, Winfried
openaire   +2 more sources